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TranscriptomicsmicroRNA expression and opioid signaling
To study the relationship between microRNAs and μ-opioid receptor (MOR) signaling, we examined microRNA expression after chronic morphine or fentanyl treatment in rat primary hippocampal neurons and in mouse hippocampus. Mouse cerebellum region was also tested as a negative control to eliminate mic...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-14268 | biostudies-arrayexpress
ProteomicsHA-MOP knockin mice express the canonical µ-opioid receptor but lack detectable splice variants
G protein-coupled receptors (GPCRs) are notoriously difficult to detect in native tissues. In an effort to resolve this problem, we have developed a novel mouse model by fusing the hemagglutinin (HA)-epitope tag sequence to the amino-terminus of the µ-opioid receptor (MOP). Although HA-MOP knock-in ...
ORGANISM(S): Mus musculus (Mouse) 
2022-12-07 | PXD027825 | Pride
Brain Mouse Pharmacology Mop splice variants Opioid receptor family Nanolc-ms/ms cid/etd Phosphorylation 
ProteomicsAgonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists
Agonists for the nociceptin/orphanin FQ opioid peptide NOP receptor, a member of the opioid receptor family, are under active investigation as novel analgesics, but their modes of signaling are less well characterized than those for other members of the opioid receptor family. Therefore, we investig...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-26 | PXD012908 | Pride
Brain Opioid receptor family Mouse Biological Pharmacology Post-translational modification Nanolc-ms/ms cid/etd Phosphorylation 
ProteomicsLigand-dependent spatiotemporal signaling profiles of the mu-opioid receptor are controlled by distinct protein-protein interaction networks
Ligand-dependent differences in the regulation and internalization of the mu-opioid receptor (MOR) have been linked to the degree of severity of the side effects that limit the use of opiates in the treatment of pain. For example, activation of the MOR by morphine and DAMGO ([D-Ala2,N-MePhe4,Gly-ol]...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD013328 | Pride
Proteomics Ras‐related c3 botulinum toxin substrate 1 (rac1) Extracellular signal regulated kinase (erk) Desmosome G protein-coupled receptor (gpcr) Cell compartmentalization Protein complex Opioid 
TranscriptomicsOpioid exacerbates gut dysbiosis in a murine model Citrobacter rodentium infection
Opioids analgesics are frequently prescribed in the United States and worldwide. However, serious side effects such as addiction, immunosuppression and gastrointestinal symptoms limit their use. It has been recently demonstrated that morphine treatment results in significant disruption in gut barrie...
ORGANISM(S): Mus musculus 
2020-02-18 | E-MTAB-7503 | biostudies-arrayexpress
GenomicsSpectrotemporal profiling of ultrasonic vocalizations during neonatal opioid withdrawal reveals a kappa opioid receptor component in female mice
Spectrotemporal profiling of ultrasonic vocalizations during neonatal opioid withdrawal reveals a kappa opioid receptor component in female mice
PRJNA1130952 | ENA
GenomicsEffect of peripheral kappa-opioid receptor agonists on murine T cells
Effect of peripheral kappa-opioid receptor agonists on murine T cells
PRJNA1483550 | ENA
Proteomicsmass spec analysis of kappa opioid receptor phosphorylation
Mass spec analysis of phosphorylation of full length Kappa opioid receptor and Kappa opioid receptor with an V2R chimeric C-terminus. The sample was purified, digested with trypsin or lys-C and analyzed with HCD, CID or ETD fragmentation methods.
ORGANISM(S): Rattus (ncbitaxon:10114) 
2026-01-12 | MSV000100439 | MassIVE
GenomicsLysosomal Downregulation of the Mu Opioid Receptor is Opposed by the Retromer Complex
Lysosomal Downregulation of the Mu Opioid Receptor is Opposed by the Retromer Complex
PRJNA1193518 | ENA
GenomicsOpioid receptor signaling suppresses leukemia by inducing TET-dependent DNA demethylation
Opioid receptor signaling suppresses leukemia by inducing TET-dependent DNA demethylation
PRJNA697941 | ENA
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