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This SuperSeries is composed of the following subset Series: GSE25099: Expression data from 57 patients with oral cancer and 22 normal persons GSE25103: Affymetrix SNP array data for oral squamous cell carcinoma Refer to individual Series
ORGANISM(S): Homo sapiens 
Oral squamous cell carcinoma (OSCC) is a solid neoplasm exhibiting aggressive tumor phenotypes with unpredictable biological behavior and usually a very unfavorable prognosis. The comprehension of the molecular basis of the variability within this cancer disease should lead to the development of sat...
ORGANISM(S): Homo sapiens 
In order to identify biomarkers that contribute to genetic causes of OSCC, we attempt to identify copy number variation regions (CNV) in patients with OSCC. We identified and confirmed the clinical significance of amplification regions scattered from 8q22.2 to 8q24.3. Affymetrix SNP arrays were perf...
ORGANISM(S): Homo sapiens 
Oral squamous cell carcinoma (OSCC) is a main reason of oral cancer mortality and morbidity. Cancer of oral cavity in central south Asia, ranks among third most common kinds of cancer. The discovery of candidate markers to differentiate normal from malignant cells in clinical diagnosis of OSCC would...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD025701 | Pride
The relationship between the microbial changes with clinical-pathological outcomes are still far from being conclusive. Herein, we investigate the ability of metagenomics (MG) and metaproteomics (MP) saliva data in distinguishing C, L0 and L1 patients. For that, we combined two strategies using MG a...
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD022859 | Pride
Establishment of a human tongue cancer organoid biobank enables early diagnosis, prognosis, and identification of therapeutic targets
Background: MicroRNAs (miRNAs) are small, non-coding, RNA molecules which regulate numerous cellular processes. Specific miRNA may be abnormally down-regulated or up-regulated in colorectal cancer and have been found associated with prognosis or response to treatments. However, no study has ever ad...
ORGANISM(S): Homo sapiens 
Considering that these potential diagnostic and prognostic targets may be regulated by events that do not imply variation in protein abundance levels, we investigated the hypothesis that changes in protein conformation can be associated with diagnosis and prognosis, revealing biological processes an...
ORGANISM(S): Homo sapiens (Human) 
2025-03-11 | PXD042574 | Pride
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