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MetabolomicsImpact of oral Chlamydia Vaccination on Host Gut Microbiome and Metabolite Composition

Chlamydia trachomatis, an intracellular pathogen, is recognized as the most common sexually transmitted bacterial infection among women worldwide. Chlamydia infections can lead to undesirable clinical outcomes, including pelvic inflammatory disease and infertility. Recently, the gut has been...

2025-11-07 | MTBLS12603 | MetaboLights
MetabolomicsSerum Metabolic Profiling of Oocyst-Induced Toxoplasma gondii Acute and Chronic Infections in Mice Using Mass-Spectrometry
Toxoplasma gondii is an obligate intracellular parasite causing severe diseases in immunocompromised individuals and congenitally infected neonates, such as encephalitis and chorioretinitis. This study aimed to determine whether serum metabolic profiling can (i) identify metabolites associated with ...
2018-04-16 | MTBLS418 | MetaboLights
MetabolomicsEctopic intestinal colonization by an oral commensal promotes C. difficile infection in Crohn’s disease
Crohn’s disease is a severe inflammatory disorder of the intestine for which there is no cure. People suffering from Crohn’s disease are at increased risk of developing Clostridioides difficile infection (CDI), which considerably exacerbates symptoms. Using a prospective observational clinical study...
2025-08-14 | MTBLS12275 | MetaboLights
MetabolomicsBioactivities of Streptomyces spp. Against selected Oral Pathogens and In silico Streptenol B interaction on pgaB of Aggregatibacter actinomycetemcomitans
Periodontal disease is an inflammatory condition affecting the tissues supporting the teeth. Biofilm formation by oral pathogens such as Aggregatibacter actinomycetemcomitans (AA) and Pseudomonas aeruginosa (PA) contribute to persistent infections and antibiotic resistance. This study evaluated the ...
2026-06-23 | MTBLS14826 | MetaboLights
TranscriptomicsMethylationEPIC array from fresh oral and oropharyngeal tissue samples from head and neck squamous cell carcinoma patients, tissue samples from potentially premalignant oral lesions and fresh tonsil tissue samples from control patients
This data was used to detect good biomarkers for head and neck squamous cell carcinoma and was integrated with transcriptome and miRNome data aiming to elucidate role of epigenetics on gene expression in head and neck squamous cell carcinoma.
ORGANISM(S): Homo sapiens 
2024-04-22 | E-MTAB-13954 | biostudies-arrayexpress
ProteomicsUltra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome
The oral cavity is home to one of the most diverse microbial community of the human body and a major entry portal for pathogens. Its homeostasis is maintained by saliva, which fulfills key functions including lubrication of food, predigesting and bacterial defense. Consequently, disruptions in saliv...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080862 | MassIVE
UnknownOral manifestations of human papillomavirus infections.
Not available
S-EPMC6174935 | biostudies-literature
Genomicshuman oral metagenome
Human oral microbiome (root canal, apical abscess, and oral cavity) Targeted Locus
PRJNA84223 | ENA
TranscriptomicsTranscription profiling of human gingival epithelial cells responses to pathogenic oral microbial species.
Transcriptional profiling was utilized to define the biological pathways of gingival epithelial cells modulated by co-culture with the oral pathogenic Porphyromonas gingivalis and Aggregatibacter (formerly actinobacillus) actinomycetemcomitans. We used microarrays to detail the global programme of g...
ORGANISM(S): Homo sapiens 
2009-04-24 | E-GEOD-9723 | biostudies-arrayexpress
UnknownOral infections in oral cancer survivors: A mini-review.
Not available
S-EPMC9634540 | biostudies-literature
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