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MetabolomicsTime-Resolved Microbiome–Metabolome Remodeling Reveals Biotransformation Patterns in Liquid-Fermented Dendrobium officinale Flowers
This study investigated temporal metabolomic changes during a 60-day mixed-culture liquid fermentation of Dendrobium officinale flowers. Fermentation supernatants were collected at days 10, 20, 30, 40, 50, and 60, with six biological replicates at each time point. Untargeted LC-MS/MS analysis was pe...
2026-07-22 | MTBLS15132 | MetaboLights
MetabolomicsUntargeted LC-MS metabolomics of redclaw crayfish gonads
Untargeted LC-MS metabolomics was performed on 20 Cherax quadricarinatus gonad samples in four groups n=5 each plus three pooled QC samples. Positive- and negative-ion mzXML files were generated using a Thermo Scientific Orbitrap Exploris 120. The submitted files contain centroided full-scan MS1 dat...
2026-09-04 | MTBLS15185 | MetaboLights
UnknownUltrasensitive NanoLC-MS of Subnanogram Protein Samples Using Second Generation Micropillar Array LC Technology with Orbitrap Exploris 480 and FAIMS PRO.
Not available
S-EPMC8253486 | biostudies-literature
MetabolomicsPGM3-Driven Hexosamine Biosynthesis Facilitates Hepatocellular Carcinoma Progression through YBX1 O-GlcNAcylation (Untargeted metabolomics)
Phosphoglucomutase 3 (PGM3) is one of the rate-limiting enzymes in the hexosamine biosynthesis pathway (HBP) and a key regulator of HBP metabolic flux. Despite the functional role of PGM3 has been validated in various tumors, its function and molecular mechanism in hepatocellular carcinoma (HCC) rem...
2026-09-03 | MTBLS15545 | MetaboLights
ProteomicsA Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients
State-of-the-art proteomics-grade mass spectrometers can measure peptide precursors and their fragments with ppm mass accuracy at sequencing speeds of tens of peptides per second with attomolar sensitivity. Here we describe a compact and robust quadrupole-orbitrap mass spectrometer equipped with a f...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2020-02-17 | PXD016662 | Pride
Faims Dia Tmt Bottom-up shotgun proteomics Phosphoproteomics Orbitrap Dda 
ProteomicsUltra-sensitive proteomics using second generation micro pillar array LC technology with Orbitrap Exploris™ 480 and FAIMS
In the light of the ongoing single-cell revolution, scientific disciplines are combining forces with the ultimate goal to retrieve as much relevant data as possible from trace amounts of biological material. For single cell proteomics, this implies optimizing the entire workflow from initial cell is...
ORGANISM(S): Homo sapiens (Human) 
2021-06-28 | PXD024017 | Pride
Micro pillar Low-input proteomics Single sell proteomics 
MetabolomicsMetabolomic profiling of colon tissue in loperamide-induced constipation mice treated with Rothia mucilaginosa

Untargeted metabolomics was performed on colon tissue from 26 C57BL/6 mice to investigate metabolic mechanisms underlying Rothia mucilaginosa-mediated constipation alleviation. Mice were divided into normal control (NC, n=8), loperamide-induced constipation model control (MC, n=8), and R. mucilag...

2026-04-27 | MTBLS13907 | MetaboLights
ProteomicsComparison of DDA (Orbitrap Exploris 480) and DIA (timsTOF Pro 2) phosphoproteomics
In this experiment, 3 replicate phosphopeptide enrichments using titanium dioxide spin tips (GL Science) of the filamentous fungus Magnaporthe oryzae were measured on a) Orbitrap Exploris 480 in DDA and b) timsTOF Pro 2 in DIA for comparison of model/acquisition type differences.
ORGANISM(S): Cellular Organisms 
2023-04-13 | PXD038605 | JPOST Repository
UnknownA Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients.
Not available
S-EPMC7124470 | biostudies-literature
ProteomicsExosomal protein Profiling in Plasma of DOCA-Salt-Induced Hypertensive and Control Mice
This study aimed to profile exosomal protein extracted from plasma of male and female mice treated with DOCA-salt (a model for hypertension) and corresponding baseline controls. The isolated exosomal proteins were sequenced using using LC-MS/MS (Orbitrap Exploris 480+FAIMS Pro). This approach may he...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD068025 | Pride
Hypertensive mice Proteomics Extracellular vesicles 
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