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TranscriptomicsAnalysis of Notch signaling on Xenopus epidermis
Analysis of epithelial explants injected with the intracellular domain of Notch (ICD) to block the formation of multi-ciliate and proton secreting cells or with dominant negative human Mastermind (HMM) to induce the formation of ectopic multi-ciliate and proton secreting cells. Results show which g...
ORGANISM(S): Xenopus laevis 
2010-08-28 | E-GEOD-23844 | biostudies-arrayexpress
TranscriptomicsTransformation of stellate cells to myofibroblasts
Activated hepatic stellate cells (HSC) that transdifferentiate to myofibroblasts in the injured liver are responsible for scar formation that leads to fibrosis and eventually cirrhosis. To investigate the gene expression profile during different stages of this process, we performed serial analysis o...
ORGANISM(S): Homo sapiens 
2006-07-01 | E-GEOD-5022 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis non-homologous end joining mutants
The proposal aims to characterise the pathways of DSB repair and recombination in Arabidopsis with the main focus of this research being the NHEJ pathway of illegitimate recombination. We will build on our expertise and resources in the field of DSB repair in plants, using the Arabidopsis NHEJ mutan...
ORGANISM(S): Arabidopsis thaliana 
2008-06-14 | E-GEOD-6178 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of quorum sensing deficient in Yersinia pestis CO92 at 37M-BM-0C
Yersinia pestis, the etiological agent of plague, is able to sense cell density by quorum sensing. The function of quorum sensing in Y. pestis is not clear. Here, the process of quorum sensing was investigated by comparing transcript profiles when three quorum-sensing synthase genes are knocked out....
ORGANISM(S): Yersinia pestis 
2013-09-05 | E-GEOD-21911 | biostudies-arrayexpress
TranscriptomicsA flexible microfluidic system for single-cell transcriptome profiling elucidates phased transcriptional regulators of cell cycle
Single cell or single nuclei RNA sequencing of mixed HEK 293 and 3T3 populations using the Nadia droplet sequencing platform. Samples cover different numbers of beads from which cDNA libraries were prepared.
ORGANISM(S): mixed sample 
2021-04-10 | E-MTAB-10296 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 5 human parental cell lines and 3 drug resistant variants by culturing the former continuously in the presence of cytotoxic drug doxorubicin
Title: Analysis of gene expression changes involved in the development of acquired drug resistance.
Description: In vitro model of drug resistance consisting of 5 parental cell lines and 3 drug resistant variants by culturing the former continuously in the presence of cytotoxic drug doxorubic...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-MIMR-11 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human keratinocytes after stimulation with recombinant human cytokines to study the events controlling cell migration)
Cellular decisions leading to a sustained cellular migration constitute a critical parameter during wound healing and metastasis. Cellular decision processes for migration involve signaling pathways as well as gene expression regulation that have been not yet studied in an integrated way. Here, hete...
ORGANISM(S): Homo sapiens 
2008-07-07 | E-TABM-440 | biostudies-arrayexpress
TranscriptomicsGene expression changes in the female zebrafish (Danio rerio) brain in response to acute exposure to methylmercury
Methylmercury (MeHg) is a potent neurotoxin and endocrine disruptor that accumulates in aquatic systems. Previous studies have shown suppression of hormone levels in both male and female fish, suggesting effects on gonadotropin regulation in the brain. We investigated the gene expression profile in ...
ORGANISM(S): Danio rerio 
2010-09-30 | E-GEOD-22662 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. pombe wild type and meu5delta cells during pat1 induced meiosis, wild type meiosis and overexpression of the mei4 transcription factor
The Meu5 RNA-binding protein stabilises its targets during meiosis. We compared wild type and meu5delta cells transcriptome under different conditions: pat1-induced meiosis in diploid cells, wild type meiosis in diploid cells and cells overexpressing the Mei4 transcription factor.
ORGANISM(S): Schizosaccharomyces pombe 
2011-01-01 | E-TABM-775 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of immortalised human mammary luminal epithelial cells and variants expressing a moderate and high level of ERBB2
To investigate changes in gene expression associated with ERBB2, expression profiling of immortalised human mammary luminal epithelial cells and variants expressing a moderate and high level of ERBB2 has been carried out using cDNA microarrays corresponding to approximately 6,000 unique genes/ESTs. ...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-SNGR-8 | biostudies-arrayexpress
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