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Metabolomics13C glucose labelling studies using 2D NMR is a useful tool for determining ex vivo whole organ metabolism during hypothermic machine perfusion of kidneys
Background: The aim of this study is to determine the feasibility of using Nuclear Magnetic Resonance (NMR) tracer studies (13C-enriched glucose) to detect ex vivo de novo metabolism in the perfusion fluid and cortical tissue of porcine kidneys during hypothermic machine perfusion (HMP). Methods: Po...
2017-10-16 | MTBLS367 | MetaboLights
ProteomicsTherapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers
Liver transplantation is the only curative option for end-stage liver disease. Donor shortages necessitate the use of higher risk donor livers, including fatty livers, which are more susceptible to ischemia reperfusion injury. Machine perfusion has improved graft utilization and is typically perform...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD056736 | Pride
Proteomics Transplant Hyperthermia Liver Machine perfusion 
ProteomicsUrine recirculation prolongs normothermic kidney perfusion for via more optimal metabolic homeostasis – a proteomics study
We describe a proteomics analysis to determine the molecular differences between normothermically perfused (normothermic machine perfusion, NMP) human kidneys with urine recirculation (URC) and urine replacement (UR). Proteins were extracted from 16 kidney biopsies with URC (n=8 donors after brain d...
ORGANISM(S): Homo sapiens (Human) 
2020-10-20 | PXD021507 | Pride
Proteomics Mass spectrometry Nephrology Kidney transplantation Ischemia reperfusion injury Organ perfusion Iri 
UnknownNormothermic Regional Perfusion Experience of Organ Procurement Organizations in the US.
Not available
S-EPMC11581661 | biostudies-literature
UnknownA Small Animal Model of Ex Vivo Normothermic Liver Perfusion.
Not available
S-EPMC6102010 | biostudies-literature
ProteomicsEx vivo lung perfusion enhances donor lung preservation in mice via Hippo signaling activation
Ex vivo lung perfusion (EVLP) is a promising technique that allows organ preservation and repair, increasing the number of marginal donor lungs for lung transplantation. This study aimed to establish an EVLP model in mice, and to unveil the molecular mechanisms responsible of EVLP beneficial effects...
ORGANISM(S): Mus Musculus 
2025-07-16 | PXD066193 |
TranscriptomicsHuman mesenchymal stromal cell expansion in a 3D scaffold-based system under direct perfusion
Development of systems allowing the maintenance of native properties of mesenchymal stromal cells (MSC) is a critical challenge for studying physiological functions of skeletal progenitors, as well as towards cellular therapy and regenerative medicine applications. Conventional stem cell culture in ...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-52896 | biostudies-arrayexpress
Unknown<i>Ex-Vivo</i> Human-Sized Organ Machine Perfusion: A Systematic Review on the Added Value of Medical Imaging for Organ Condition Assessment.
Not available
S-EPMC11408214 | biostudies-literature
TranscriptomicsTranscription profiling of human samples from intervention study with two doses of iron (as ferrous gluconate via intestinal perfusion) to study the effect on genome wide gene expression in the small intestine
Human intervention study with two doses of iron (as ferrous gluconate via intestinal perfusion) to study the effect on genome-wide gene expression in the small intestine, in order to obtain detailed information about intestinal transcriptomics in vivo.
ORGANISM(S): Homo sapiens 
2006-05-01 | E-MEXP-325 | biostudies-arrayexpress
UnknownSense and Sensibilities of Organ Perfusion as a Kidney and Liver Viability Assessment Platform.
Not available
S-EPMC8958413 | biostudies-literature
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