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MetabolomicsOrganotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations
BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic in...
2019-02-08 | MTBLS669 | MetaboLights
MetabolomicsMetabolomics revealed the influence of breast cancer on lymphatic endothelial cell metabolism, metabolic crosstalk, and lymphangiogenic signaling in co-culture

Breast cancer metastasis occurs via blood and lymphatic vessels. Breast cancer cells 'educate' lymphatic endothelial cells (LECs) to support tumor vascularization and growth. However, despite known metabolic alterations in breast cancer, it remains unclear how lymphatic endothelial cell metabolis...

2024-06-25 | MTBLS859 | MetaboLights
TranscriptomicsA novel 3-D organotypic culture model by co-culturing alpha-SMA positive CAF and cholangiocarcinoma cells in a collagen matrix
The increased M-NM-1-smooth muscle-actin positive cancer-associated fibroblastic cells (CAF) in the desmoplastic stroma may relate to a more aggressive cancer and worse survival outcomes for intrahepatic cholangiocarcinoma (ICC) patients We developed a novel 3-D organotypic culture model by co-cultu...
ORGANISM(S): Rattus norvegicus 
2012-06-22 | E-GEOD-38889 | biostudies-arrayexpress
ProteomicsAn organotypic model of human skin simulates the dermonecrotic effects of Naja nigricollis envenoming
Snakebite envenoming is a neglected tropical disease that kills and maims hundreds of thousands annually. Naja nigricollis, the black-necked spitting cobra, has a cytotoxin-rich venom that is able to cause severe dermonecrosis and is not efficiently neutralized by current antivenoms. Here, we introd...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2023-01-11 | PXD033111 | Pride
Dermonecrosis Snakebite envenoming Naja nigricollis Skin organotypic Proteomics Cytotoxin Keratinocyte 3d cell culture Dda Lc-ms/ms 
TranscriptomicsA comparison of mono-culture and co-culture model containing fibroblasts
Organotypic three dimensional cultures of epithelial cells are grown at the air–liquid interface (ALI) and resemble the in vivo counterparts. Although the complexity of in vivo cellular responses could be better manifested in co-culture models in which additional cell-types such as fibroblasts were ...
ORGANISM(S): Homo sapiens 
2015-06-12 | E-MTAB-3462 | biostudies-arrayexpress
TranscriptomicsPeriostin, a cell adhesion molecule, facilitates invasion in the tumor microenvironment and annotates a novel tumor invasive signature in esophageal cancer
Human squamous cell cancers are the most common epithelially derived malignancies. One example is esophageal squamous cell carcinoma (ESCC), which is associated with a high mortality rate that is related to a propensity for invasion and metastasis. We report that periostin, a highly expressed cell a...
ORGANISM(S): Homo sapiens 
2010-07-08 | E-GEOD-21293 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of normal human bronchial epithelial cells in 2D and 3D cultural conditions
The experiment is part of a project to study DNA repair process after ionizing radiation in organotypic 3-dimentional human bronchial epithlial cell culture. Human bronchial epithelial cells were grown in tissue culture flask (2D) or in matrics gel (3D). Three independent cultures were done for eac...
ORGANISM(S): Homo sapiens 
2011-07-26 | E-GEOD-27520 | biostudies-arrayexpress
ProteomicsThe Hepatocyte Proteome in Organotypic Rat Liver Models and the Influence of the Local Microenvironment
Liver models that closely mimic the in vivo microenvironment are central for understanding liver functions, capabilities, and intercellular communication processes. Whereas hepatocyte monolayers de-differentiate after only a few days in culture, constructs consisting of hepatocytes and non-parenchym...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-07-06 | PXD002491 | Pride
In vitro Hepatocyte Organotypic Liver 
TranscriptomicsAssessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarettes on gingival organotypic cultures (miRNA data)
Swedish snus is a smokeless tobacco product that contains reduced levels of harmful compounds compared with cigarette smoke. In Sweden, where snus use exceeds smoking among men, relatively low rates of major smoking-related diseases have been recorded. To better understand how snus use could align w...
ORGANISM(S): Homo sapiens 
2019-01-30 | E-MTAB-7580 | biostudies-arrayexpress
TranscriptomicsAssessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarettes on gingival organotypic cultures (mRNA data)
Swedish snus is a smokeless tobacco product that contains reduced levels of harmful compounds compared with cigarette smoke. In Sweden, where snus use exceeds smoking among men, relatively low rates of major smoking-related diseases have been recorded. To better understand how snus use could align w...
ORGANISM(S): Homo sapiens 
2019-01-30 | E-MTAB-7579 | biostudies-arrayexpress
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