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TranscriptomicsTranscription profiling of mouse uterine response to estrogen 17-beta-estradiol, the phytoestrogen genistein, and the synthetic estrogen diethylstilbestrol
We used gene expression profiling to investigate whether the molecular effects induced by estrogens of different provenance are intrinsically similar. In this article we show that the physiologic estrogen 17-beta-estradiol, the phytoestrogen genistein, and the synthetic estrogen diethylstilbestrol a...
ORGANISM(S): Mus musculus 
2022-11-20 | E-AFMX-13 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse uterine response 1, 2, 4, 8, 24, 48, and 72 hr after exposure to the reference physiologic estrogen 17 beta-estradiol (E2)
A major challenge in the emerging field of toxicogenomics is to define the relationships between chemically induced changes in gene expression and alterations in conventional toxicologic parameters such as clinical chemistry and histopathology. We have explored these relationships in detail using th...
ORGANISM(S): Mus musculus 
2022-11-20 | E-AFMX-12 | biostudies-arrayexpress
TranscriptomicsGene expression data from 62 colorectal cancers
We stratified colorectal tumor samples using a new unsupervised, iterative method based on non-negative matrix factorization (NMF). The resulting five subtypes exhibited activation of specific signaling pathways, and significant differences in microsatellite status and tumor location. We could also ...
ORGANISM(S): Homo sapiens 
2013-01-14 | E-GEOD-35896 | biostudies-arrayexpress
UnknownThe need to decide if all estrogens are intrinsically similar.
Not available
S-EPMC1247471 | biostudies-literature
UnknownSubtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.
Not available
S-EPMC3543849 | biostudies-literature
TranscriptomicsFull genome expression profiling of primary colorectal cancer (CRC)
Fresh-frozen primary tumor samples from CRC patients were analyzed from their gene expression. Full genome unsupervised clustering identified three intrinsic subtypes that are associated with tumor and clinical characteristics. Primary CRC samples (188) were hybridzed against a common colon cancer r...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-42284 | biostudies-arrayexpress
UnknownTranscription profiling of human breast cancer cells expressing ERalpha and treated with 17beta-estradiol
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-2251 | biostudies-other
TranscriptomicsTranscription profiling of human breast cancer cells expressing ERalpha and treated with 17beta-estradiol
Gene expression changes caused by estrogen treatment of breast cancer cells that re-express ERalpha was investigated by infecting ER-negative MDA-MB-231 breast cancer cells for 24 h with recombinant adenovirus encoding full-length human ERalpha (Ad-ERalpha) or control vector (Ad-LacZ), and treating ...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2251 | biostudies-arrayexpress
UnknownColorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition.
Not available
S-EPMC4234005 | biostudies-literature
UnknownPhenotypic anchoring of gene expression changes during estrogen-induced uterine growth.
Not available
S-EPMC1247656 | biostudies-literature
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