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ProteomicsRepurposing Herpesvirus Protein ORF57 to Inhibit TDP-43 Aggregation
The integrated stress response (ISR) is a major element of translation control. The ISR is beneficial in responding to acute stresses, but in human disease a chronic, persistent stress response can contribute to the disease process. Many studies manipulate the ISR by targeting just one protein. Howe...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD039246 | Pride
Translational stress response Alzheimer’s disease Als Protein aggregation Tdp-43 
UnknownOutcome of pediatric non-Hodgkin lymphoma in Central America: A report of the Association of Pediatric Hematology Oncology of Central America (AHOPCA).
Not available
S-EPMC6428601 | biostudies-literature
ProteomicsAlzheimer’s Disease-Associated circPDE4B Triggers Translation Stress Pathways
In the intricate landscape of Alzheimer’s disease (AD) pathology, circular RNAs(circRNA) are emerging as influential players, orchestrating crucial aspects of gene expression, synaptic plasticity, and neuronal function. In this study, we characterize the biological role of circPDE4B, a highly abunda...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD070615 | Pride
Gemin5 Stress Circpde4b Translation Alzheimer's disease 
UnknownMolecular subgroups of T-cell acute lymphoblastic leukemia in adults treated according to pediatric-based GMALL protocols.
Not available
S-EPMC11147771 | biostudies-literature
TranscriptomicsGenome-wide mRNA expression profiles induced by infection with the pandemic and seasonal influenza A viruses in macrophages
Infection with pandemic A/H1N1 influenza virus induces high levels of circulating and lung pro-inflammatory cytokines and chemokines in experimental models and humans. These inflammatory mediators contribute to poor clinical outcomes of this infection. To compare the regulation of inflammatory respo...
ORGANISM(S): Homo sapiens 
2012-06-09 | E-GEOD-36012 | biostudies-arrayexpress
UnknownMulticenter Trial of a Tubeless, On-Body Automated Insulin Delivery System With Customizable Glycemic Targets in Pediatric and Adult Participants With Type 1 Diabetes.
Not available
S-EPMC8323171 | biostudies-literature
UnknownDonanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial.
Not available
S-EPMC10352931 | biostudies-literature
UnknownGlobal Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study.
Not available
S-EPMC7755038 | biostudies-literature
UnknownErtugliflozin and Slope of Chronic eGFR: Prespecified Analyses from the Randomized VERTIS CV Trial.
Not available
S-EPMC8729577 | biostudies-literature
UnknownAdd-On Treatment With Zilebesiran for Inadequately Controlled Hypertension: The KARDIA-2 Randomized Clinical Trial.
Not available
S-EPMC12120674 | biostudies-literature
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