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TranscriptomicsGenome-wide analysis of snRNAs bound to Gemin5 upon protein synthesis inhibition
Here, we report the genome-wide analysis of snRNAs that are bound to Gemin5 upon protein synthesis inhibition. Upon protein synthesis inhibition, the SMN complex that has a crucial role in the biogenesis of snRNPs dissociates into its subunits, leaving Gemin5 alone. The existence of these subunits w...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20751 | biostudies-arrayexpress
ProteomicsHuman HEK293 Gemin5 phosphorylation site T897 mutants LC-MSMS
Identification of cellular proteins interacting with Gemin5 phosphorylation mutants in T897 residue. We used the T897A mutant as phosphorylation defective protein and the T897E mutant as phosphomimetic. P85 C-terminal fragment of Gemin5 has been used to purify the protein complexes associated by Tan...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035227 | Pride
Human Gemin5 Hek293 Phosphorylation 
ProteomicsHuman HEK293 Gemin5 clinical variants LC-MSMS
Identification of cellular proteins interacting with Gemin5 variants found in patients with neurological disorders. P85 C-terminal fragment of Gemin5 has been used to purify the protein complexes associated by Tandem Affinity Purification. The study has been performed using two biological replicates...
ORGANISM(S): Homo sapiens (Human) 
2022-04-06 | PXD028959 | Pride
Human Gemin5 Lc-msms Clinical variants Hek293 
UnknownSMN regulates GEMIN5 expression and acts as a modifier of GEMIN5-mediated neurodegeneration.
Not available
S-EPMC11348892 | biostudies-literature
GenomicsAlternative splicing events driven by altered levels of Gemin5 undergo translation
Alternative splicing events driven by altered levels of Gemin5 undergo translation
PRJNA1087300 | ENA
GenomicsGemin5-dependent RNA association to polysomes supports selective translation of mRNA subsets
Gemin5-dependent RNA association to polysomes supports selective translation of mRNA subsets
PRJNA824426 | ENA
GenomicsMutations in GEMIN5 cause a neurodevelopmental ataxia syndrome by a loss-of-1function mechanism
Mutations in GEMIN5 cause a neurodevelopmental ataxia syndrome by a loss-of-1function mechanism
PRJNA713291 | ENA
OtherRNA maps of the non-canonical RNA-binding site of Gemin5
We report the CLIP-seq data of the non-canonical RNA-binding site of Gemin5. This region consists of two domains, RBS1 and RBS2, differing in their RNA-interaction features. Interestingly, the most abundant RNA target of the RBS1 polypeptide was the Gemin5 mRNA. Biochemical and functional characteri...
ORGANISM(S): Homo sapiens 
2018-08-30 | GSE102268 | GEO
UnknownStructural basis for Gemin5 decamer-mediated mRNA binding.
Not available
S-EPMC9440017 | biostudies-literature
TranscriptomicsMutations in GEMIN5 cause a neurodevelopmental ataxia syndrome by a loss-of-1function mechanism
GEMIN5 is a critical component of snRNP assembly complex. Patients carrying novel autosomal recessive variants in the GEMIN5 gene showed symptoms of developmental delay, central hypotonia, and cerebellar ataxia which are distinct than classical spinal muscular atrophy. We performed RNA-seq analysis ...
ORGANISM(S): Homo sapiens 
2021-03-11 | GSE168622 | GEO
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