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UnknownGenomic-Guided Conservation Actions to Restore the Most Endangered Conifer in the Mediterranean Basin.
Species with extremely small population sizes are critically endangered because of reduced genetic diversity, increased inbreeding and hybridisation threats. Genomic tools significantly advance conservation by revealing genetic insights into endangered species, notably in monitoring frameworks. Sici...
S-EPMC12684301 | biostudies-literature
UnknownProcalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients.

Purpose

Although the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters of patients received antibiotics. We aim to investigate whether procalciton...
S-EPMC10425511 | biostudies-literature
UnknownGenetic polymorphism of Trypanosoma cruzi bloodstream populations in adult chronic indeterminate Chagas disease patients from the E1224 clinical trial.

Background

The role that the genetic diversity of natural Trypanosoma cruzi populations plays in response to trypanocidal treatment of chronic Chagas disease (CD) patients remains to be understood. We analysed the genetic polymorphisms of parasite bloodstream populations infecting chronic CD...
S-EPMC8865008 | biostudies-literature
UnknownMulti-ancestry genome-wide association study of asthma exacerbations.

Background

Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior st...
S-EPMC9671132 | biostudies-literature
UnknownIdentification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study.

Background

The clinical presentation of COVID-19 in patients admitted to hospital is heterogeneous. We aimed to determine whether clinical phenotypes of patients with COVID-19 can be derived from clinical data, to assess the reproducibility of these phenotypes and correlation with prognosis,...
S-EPMC7906623 | biostudies-literature
TranscriptomicsGene expression from Gaucher Disease iPSc
Gene expression data obtained from induced pluripotent stem cells derived from wild type fibroblasts (iPSc WT) and from Gaucher Disease type 2 fibroblasts (GD iPSc). Also, gene expression analysis from the initial fibroblasts was made (WT fibroblasts and GD- fibroblasts), as well as gene expression ...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-41243 | biostudies-arrayexpress
UnknownEffect of the vaginal microbiome on the pregnancy rate in women receiving assisted reproductive treatment.

Purpose

To investigate if the vaginal microbiome influences the IVF outcome.

Methods

Thirty-one patients undergoing assisted reproductive treatment (ART) with own or donated gametes and with cryotransfer of a single euploid blastocyst were recruited for this cohort study. Two vaginal ...
S-EPMC6823330 | biostudies-literature
UnknownUsefulness of Serial Blood Sampling and PCR Replicates for Treatment Monitoring of Patients with Chronic Chagas Disease.
This work evaluated a serial blood sampling procedure to enhance the sensitivity of duplex real-time quantitative PCR (qPCR) for baseline detection and quantification of parasitic loads and posttreatment identification of failure in the context of clinical trials for treatment of chronic Chagas dise...
S-EPMC6355557 | biostudies-literature
TranscriptomicsGenetic characterization of tumor-stage mycosis fungoides
Mycosis fungoides patients who develop tumors or extracutaneous involvement usually have a poor prognosis with no curative therapy available so far. In the present EORTC multicenter study, the genomic profile of 41 skin biopsies from tumor-stage mycosis fungoides was analyzed using a high-resolution...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-18098 | biostudies-arrayexpress
UnknownFirst external quality assurance program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease.
Real-Time PCR (qPCR) testing is recommended as both a diagnostic and outcome measurement of etiological treatment in clinical practice and clinical trials of Chagas disease (CD), but no external quality assurance (EQA) program provides performance assessment of the assays in use. We implemented an E...
S-EPMC5703561 | biostudies-literature
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