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MetabolomicsBiomarker Discovery in Oral Cancer (OSMF & OSCC) and its severity

Oral squamous cell carcinoma (OSCC) is frequently the outcome of oral submucous fibrosis (OSMF), a common possibly premalignant disease. In our study, a cohort of 50 patients with OSCC and OSMF, along with 50 healthy controls, was analyzed to identify significant metabolic differences between the...

2024-10-23 | MTBLS11009 | MetaboLights
MetabolomicsMechanistic study of the effects of salivary components from OSCC patients on tumor growth using a mouse model of oral squamous cell carcinoma

Mechanistic study of the effects of salivary components from OSCC patients on tumor growth using a mouse model of oral squamous cell carcinoma

2025-08-01 | MTBLS12805 | MetaboLights
TranscriptomicsMicroRNA profiling by array of oral squamous cell cancer (OSCC) surgical margins defined by narrow band imaging.
The purpose of this study was to provide molecular evidence that surgical margin definition using narrow band imaging (NBI) resulted in more complete OSCC excision that conventional while light (WL) imaging. Samples were taken prospectively from 18 patients undergoing surgical resection for intraora...
ORGANISM(S): Homo sapiens 
2018-02-09 | E-MTAB-6470 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of oral squamous cell cancer (OSCC) surgical margins defined by narrow band imaging.
The purpose of this study was to provide molecular evidence that surgical margin definition using narrow band imaging (NBI) resulted in more complete OSCC excision that conventional while light (WL) imaging. Samples were taken prospectively from 18 patients undergoing surgical resection for intraora...
ORGANISM(S): Homo sapiens 
2018-01-17 | E-MTAB-5933 | biostudies-arrayexpress
TranscriptomicsExpression data from oral squamous cell carcinoma (OSCC)-derived cell lines and normal oral keratinocytes
Oral squamous cell carcinoma (OSCC) is a lethal disease and early death usually occurs as a result of local invasion and regional lymph node metastases. We used microarrays to identify down or upregulated genes in OSCCs compared with non-malignant controls. To identify genes whose transcription is d...
ORGANISM(S): Homo sapiens 
2011-09-01 | E-GEOD-31853 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of oral squamous cell carcinoma (OSCC)
According to epidemiological studies, a vast majority, approximately 80%~90% of male OSCC patients in Taiwan habitually drink alcohol (A), and chew betel quid (B), and use cigarette (C). To assess the impact of these dietary factors on the epigenome, we conduct a high-throughput screen survey in an ...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-38532 | biostudies-arrayexpress
TranscriptomicsExpression data from 57 patients with oral cancer and 22 normal persons
In order to aid the development of patient-tailored diagnostics and therapeutics, we attempted to identify a genetic signature associated with disease prognosis in OSCC. A genome-wide analysis of transcription with the Affymetrix GeneChip Human Gene 1.0 ST Array was conducted. In this dataset, we i...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-25099 | biostudies-arrayexpress
TranscriptomicsIdentification of oral carcinoma miRNA involved in Wnt/b-catenin signaling
MicroRNAs (miRNAs) participate in many biological processes and have emerged as key players in carcinogenesis. In order to identify changes in miRNAs specific for betelquid-associated oral squamous cell carcinoma (OSCC), we investigated the expression profiles of 858 miRNAs in a panel of 40 pairs of...
ORGANISM(S): Homo sapiens 
2015-01-07 | E-GEOD-45238 | biostudies-arrayexpress
TranscriptomicsA 13-gene signature prognostic of HPV-negative OSCC: discovery and external validation
OSCC is associated with substantial mortality and morbidity. In this study, we built on our previous molecular work to identify and validate a prognostic 13-gene signature that showed a higher ability than tumor stage in predicting survival for patients with HPV-negative oral squamous cell carcinoma...
ORGANISM(S): Homo sapiens 
2013-03-07 | E-GEOD-41613 | biostudies-arrayexpress
TranscriptomicsOSCC Illumina GoldenGate Methylation
This study aims to compare the DNA methylome across a large cohort of oral squamous cell carcinoma and matched normal samples. DNA from 44 OSCCs and paired normal mucosa were analysed using Illumina GoldenGate methylation array. This data was correlated with extracapsular spread (extracapsular sprea...
ORGANISM(S): Homo sapiens 
2013-08-02 | E-MTAB-1298 | biostudies-arrayexpress
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