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ProteomicsTargeting G1–S Checkpoint–Compromised Cancers with Cyclin A/B RxL Inhibitors
Cancer cell proliferation requires precise control of E2F1 activity; excess activity promotes apoptosis. Here, we developed cell-permeable and bioavailable macrocycles that selectively kill small cell lung cancer (SCLC) cells with inherent high E2F1 activity by blocking RxL-mediated interactions of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD055112 | Pride
Macrocycle Cyclin a E2f Cyclin b Cy/rxl motif Cdk2 Sac Synthetic lethality 
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
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