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ProteomicsThe impact of E2F/Dp inactivation on metabolism differs between muscles and fat body cells
We aim to determine the physiological impact of inactivating E2F in muscles and in adipose cells in vivo. To uncover the mechanism of action of E2F in each tissue we investigated the similarities between E2F-deficient tissues by comparing the proteomic profiles between muscles and fat cells. Our fin...
ORGANISM(S): Drosophila Melanogaster (ncbitaxon:7227) 
2021-02-11 | MSV000086854 | MassIVE
TranscriptomicsE2F in vivo binding specificity: comparison of consensus vs. non-consensus binding sites
Recent genome-scale ChIP-chip studies of transcription factors have shown that a low percentage of experimentally determined binding sites contain the consensus motif for the immunoprecipitated factor. In most cases, differences between in vivo target sites that contain or lack a consensus motif ha...
ORGANISM(S): Mus musculus 
2008-10-01 | E-GEOD-12126 | biostudies-arrayexpress
TranscriptomicsA ChIP-chip analysis of E2F family in normal and tumor cells reveals interchangeable roles of E2F family members
Using ChIP-chip assays, we examined the binding patterns of three members of E2F family in five different cell types. Keywords: ChIP-chip We used ENCODE arrays to determine the loaction of E2F family, then identify their binding motifs in vivo. We used promoter arrays to assess the relationship of E...
ORGANISM(S): Homo sapiens 
2007-08-22 | E-GEOD-8716 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human melanoma cell line after Adenovirus-mediated E2F-1 gene transfer
E2F-1 gene expression profiling by adenovirus-mediated gene transfer in SKMEL-2 melanoma cell line.
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-1562 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human SK-MEL-2 melanoma cell line transfected with E2F-1 and doxorubicin or transfected with a LacZ control plus doxorubicin to investigate the molecular mechanisms of a combination of E2F-1 gene therapy and chemotherapy.
SK-MEL-2 cells treated with Ad-E2F-1 (MOI 2), Ad-E2F-1 (MOI 2)plus doxorubicin 0.1uM, or Ad-LacZ (MOI 2) plus doxorubicin 0.1uM. The combination of E2F-1 gene therapy and chemotherapy produces a synergistic effect on melanoma cell apoptosis. However, the molecular mechanisms have not been fully eluc...
ORGANISM(S): Homo sapiens 
2007-10-27 | E-GEOD-2715 | biostudies-arrayexpress
TranscriptomicsIn vivo disruption of Rb-E2F-Ezh2 signaling loop causes bladder cancer development
Bladder cancer (BC) is a highly prevalent human disease in which Rb pathway inactivation and epigenetic alterations are common events. However, the connection between these two processes is still poorly understood. Here we show that the in vivo inactivation of all Rb family genes in the mouse urothe...
ORGANISM(S): Homo sapiens 
2014-10-02 | E-GEOD-38264 | biostudies-arrayexpress
TranscriptomicsA retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene targeted mice
The retinoblastoma protein (pRB) is best known for regulating cell proliferation through E2F transcription factors. In this report we investigate the properties of a targeted mutation that disrupts pRB interactions with the transactivation domain of E2Fs. Mice that carry this mutation endogenously (...
ORGANISM(S): Mus musculus 
2014-04-14 | E-GEOD-54924 | biostudies-arrayexpress
GenomicsERa-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer
This SuperSeries is composed of the following subset Series: GSE22533: Breast cancer cells resistant to hormone deprivation maintain an estrogen receptor alpha-dependent, E2F-directed transcriptional program GSE27300: Estrogen-independent genomic ER binding analysis Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-05-14 | E-GEOD-37955 | biostudies-arrayexpress
Transcriptomicsp53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation
Analysis of miRNA expression in human breast cancer samples with Agilent's miRNA arrays. These samples are part of a study where we have investigated the mammalian cell proliferation control network consisting of transcription regulators, E2F and p53, their targets, and a family of 14 microRNAs. We ...
ORGANISM(S): Homo sapiens 
2008-09-22 | E-GEOD-12848 | biostudies-arrayexpress
ModelsYan2012 - Rb-E2F pathway dynamics with miR449
MiRNAs, which are a family of small non-coding RNAs, regulate a broad array of physiological and developmental processes. However, their regulatory roles have remained largely mysterious. E2F is a positive regulator of cell cycle progression and also a potent inducer of apoptosis. Positive feedback ...
2024-09-02 | BIOMD0000000720 | BioModels
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