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TranscriptomicsGenome-wide inter-primate comparison of gene expression profiles in multiple tissues
Regulatory changes have long been hypothesized to play an important role in primate evolution. To identify adaptive regulatory changes in humans, we performed a genome-wide survey for genes whose regulation evolves under natural selection. To do so, we used a novel multi-species microarray to measur...
ORGANISM(S): Macaca mulatta 
2008-09-17 | E-GEOD-11560 | biostudies-arrayexpress
TranscriptomicsPenicillium marneffei: Gene expression profiling of hyphal and yeast cells and during conidiation
Penicillium marneffei (Talaromyces marneffei) is an opportunistic human pathogen that can grow in a multicellular hyphal form at 25M-BM-0C or a unicellular fission yeast form at 37M-BM-0C, and can switch between these two forms in response to temperature. The yeast form is found in infected individu...
ORGANISM(S): Talaromyces marneffei 
2013-11-21 | E-GEOD-51109 | biostudies-arrayexpress
TranscriptomicsPurification and transcriptomic analysis of mouse fetal Leydig cells reveals candidate genes for disorders of sex development
To examine the transcriptome of early testicular somatic cells during gonadogenesis at 12.5dpc RNA sequencing (RNA-Seq) was performed on murine primary testicular cell lineages isolated from the Sf1-eGFP line by FACS. The three main somatic cell lineages of the testis were isolated: the Sertoli cell...
ORGANISM(S): Mus musculus 
2015-05-21 | E-GEOD-65498 | biostudies-arrayexpress
TranscriptomicsPenicillium marneffei: Gene expression profiling during the dimorphic switch
Penicillium marneffei (Talaromyces marneffei) is an opportunistic human pathogen that can grow in a multicellular hyphal form at 25M-BM-0C or a unicellular fission yeast form at 37M-BM-0C, and can switch between these two forms in response to temperature. The yeast form is found in infected individu...
ORGANISM(S): Talaromyces marneffei 
2013-11-21 | E-GEOD-51110 | biostudies-arrayexpress
TranscriptomicsAssociation of genes regulated by Ezh2 and trimethylation of histone 3 lysine 27
Differentiation of naïve CD4+ T cells into effector (Th1, Th2 and Th17) and induced regulatory (iTreg) T cells requires lineage-specifying transcription factors and epigenetic modifications that allow appropriate repression or activation of gene transcription. The epigenetic silencing of cytokine ge...
ORGANISM(S): Mus musculus 
2014-08-04 | E-GEOD-57500 | biostudies-arrayexpress
TranscriptomicsDNA methylation differences between human regulatory T cells and conventional T cells
Regulatory T cells (Treg) prevent the emergence of autoimmune disease. Prototypic natural Treg (nTreg) are programmed by Forkhead-box P3 (FOXP3) and can be reliably identified by demethylation at the FOXP3 locus. To explore the nTreg methylation landscape we performed genome-wide methylation studies...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-49667 | biostudies-arrayexpress
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