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MetabolomicsOsmolality-based normalization enhances statistical discrimination of untargeted metabolomic urine analysis: results from a comparative study

INTRODUCTION: Because of its ease of collection, urine is one of the most commonly used matrices for metabolomics studies. However, unlike other biofluids, urine exhibits tremendous variability that can introduce confounding inconsistency during result interpretation. Despite man...

2023-09-04 | MTBLS1765 | MetaboLights
TranscriptomicsOsmolality as a major regulator of the transcriptome and metabolome in kidney collecting duct cells
We hypothesized that altered extracellular osmolality per se could affect the transcriptome of the kidney inner medullary collecting duct (IMCD) cells, and hence it might change renal tubular function. The data sets of transcriptomics were incorporated into the "omic" data sets of metabolo...
ORGANISM(S): Rattus norvegicus 
2012-02-09 | E-GEOD-35598 | biostudies-arrayexpress
TranscriptomicsExpression data from bovine nucleus pulposus interverteral disc cells
Assessment of the putative differential gene expression profiles in high osmolality-treated bovine nucleus pulposus intervertebral disc cells for a short (5 h) and a long (24 h) time period. Identification of novel genes up- or down-regulated as an early or a late response to hyperosmotic stress. A ...
ORGANISM(S): Bos taurus 
2015-06-19 | E-GEOD-59485 | biostudies-arrayexpress
ProteomicsEvaluation of burbot Lota lota spermatozoon motility, lipid composition, protein profile, and swelling rate following change of temperature and osmolality
Despite available information on the roles of osmotic pressure, potassium (K+), and calcium (Ca2+) in activation of Eurasian burbot spermatozoon motility, the changes in sperm biochemical composition and mechanisms underlying their activation at temperatures above optimal spawning temperature is sti...
ORGANISM(S): Lota lota 
2022-09-20 | PXD027402 | Pride
Biomolecule Protein Fish lipid Sperm activation Osmolality 
TranscriptomicsOsmolality as a major regulator of the transcriptome and metabolome in kidney collecting duct cells
We hypothesized that altered extracellular osmolality per se could affect the transcriptome of the kidney inner medullary collecting duct (IMCD) cells, and hence it might change renal tubular function. The data sets of transcriptomics were incorporated into the "omic" data sets of metabolomics. Prim...
ORGANISM(S): Rattus norvegicus 
2012-02-09 | GSE35598 | GEO
GenomicsKidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients [Drop-seq]
Kidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients [Drop-seq]
PRJNA607962 | ENA
GenomicsKidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients [single nuclei]
Kidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients [single nuclei]
PRJNA607967 | ENA
GenomicsVascular calcification is accelerated by hyponatremia and low osmolality condition via activating Rac1-Akt pathway
Vascular calcification is accelerated by hyponatremia and low osmolality condition via activating Rac1-Akt pathway
PRJNA996930 | ENA
GenomicsKidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients [bulk RNA-seq]
Kidney single-cell transcriptomes predict spatial corticomedullary gene expression and tissue osmolality gradients [bulk RNA-seq]
PRJNA607959 | ENA
GenomicsProlactin, cortisol, and extracellular osmolality regulate cftr, ostf1, and sgk1 in tilapia ionocytes
Prolactin, cortisol, and extracellular osmolality regulate cftr, ostf1, and sgk1 in tilapia ionocytes
PRJNA1434396 | ENA
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