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GenomicsThe Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis. [ChIP_seq]
Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and S...
ORGANISM(S): Mus musculus 
2012-04-09 | E-GEOD-30972 | biostudies-arrayexpress
TranscriptomicsGene expression in macrophages stimulated with LPS in conditions allowing or inhibiting NFAT activation
Macrophages and dendritic cells (DCs) differently contribute to the generation of coordinated immune system responses against infectious agents. They interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorg...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-15721 | biostudies-arrayexpress
TranscriptomicsGene expression in dendritic cells stimulated with LPS in conditions allowing or inhibiting NFAT activation
Interleukin-2 (IL-2) is one of the molecules produced by mouse dendritic cells (DCs) after stimulation by Toll like receptor (TLR) agonists. By analogy with the events following T-cell receptor (TCR) engagement leading to IL-2 production we have observed that DC stimulation with lipopolysaccharide (...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-15718 | biostudies-arrayexpress
TranscriptomicsApoptosis genes specifically modulated by NFAT in LPS-activated dendritic cells
Dendritic cells (DCs) are a special class of leukocytes able to activate both innate and adaptive immune responses. They interact with microbes through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms. Upon antigen binding,...
ORGANISM(S): Mus musculus 
2010-03-03 | E-GEOD-15720 | biostudies-arrayexpress
TranscriptomicsMonocyte-derived IL-1 and IL-6 are differentially required for cytokine release syndrome and neurotoxicity by CAR-T cells.
Single-cell transcriptome profiling using a 3' droplet-based platform (Chromium,10x Genomics) of human CD45+ leukocytes isolated from leukemic HuSGM3 mice infused with CD19.28z CAR-T cells, two days after cytokine release syndrome (CRS) onset and 5 days later.
ORGANISM(S): Homo sapiens 
2018-05-24 | E-MTAB-6505 | biostudies-arrayexpress
TranscriptomicsLatent enhancers unveiled by stimulation expand and adapt the available cis-regulatory repertoire (RNA-seq)
According to current models, transcription factors (TFs) activated by extracellular stimuli operate in the context of a pre-established enhancer repertoire induced and maintained by lineage-specific TFs. Here, we uncovered the existence of latent enhancers, defined as regions of the genome that in t...
ORGANISM(S): Mus musculus 
2013-01-17 | E-GEOD-38371 | biostudies-arrayexpress
GenomicsThe Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis
This SuperSeries is composed of the following subset Series: GSE30971: The Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis. [Expression Profile] GSE30972: The Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor...
ORGANISM(S): Mus musculus 
2012-04-08 | E-GEOD-30973 | biostudies-arrayexpress
TranscriptomicsA dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages.
IThe transcription factor (TF) interferon regulatory factor 8 (IRF8) controls both developmental and inflammatory stimulus-inducible genes in macrophages, but the mechanisms underlying these two different functions are largely unknown. One possibility is that these different roles are linked to the ...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-56122 | biostudies-arrayexpress
TranscriptomicsThe Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis. [Expression Profile]
Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and S...
ORGANISM(S): Mus musculus 
2012-04-08 | E-GEOD-30971 | biostudies-arrayexpress
GenomicsA dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages.
The transcription factor (TF) interferon regulatory factor 8 (IRF8) controls both developmental and inflammatory stimulus-inducible genes in macrophages, but the mechanisms underlying these two different functions are largely unknown. One possibility is that these different roles are linked to the a...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-56121 | biostudies-arrayexpress
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