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UnknownOTS964, a TOPK Inhibitor, Is Susceptible to ABCG2-Mediated Drug Resistance.
Not available
S-EPMC7917255 | biostudies-literature
UnknownCrystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964.
Not available
S-EPMC9722545 | biostudies-literature
GenomicsEffect of CDK11 inhibition via OTS964 treatment on gene expression to assess implication on cellular processes including intron retention.
Effect of CDK11 inhibition via OTS964 treatment on gene expression to assess implication on cellular processes including intron retention.
PRJNA1321777 | ENA
Unknown[18F]FE-OTS964: a Small Molecule Targeting TOPK for In Vivo PET Imaging in a Glioblastoma Xenograft Model.
Not available
S-EPMC6482100 | biostudies-literature
TranscriptomicsEffect of CDK11 inhibition via OTS964 treatment on gene expression to assess implication on cellular processes including intron retention.
CDK11 has known to have functions in the cell cycle and RNA processing. It has been previously shown that, a mutation within CDK11 (G579S) confers resistance to CDK11 inhibition. To further understand the role of CDK11 in cancer, we performed RNA-sequencing in four cancer cell lines (A375, Cal51, DL...
ORGANISM(S): Homo sapiens 
2025-09-09 | GSE307472 | GEO
UnknownThe combined efficacy of OTS964 and temozolomide for reducing the size of power-law coded heterogeneous glioma stem cell populations.
Not available
S-EPMC6481323 | biostudies-literature
ProteomicsCryo-EM structure of the CDK11-cyclin L-SAP30BP complex reveals mechanisms of CDK11 regulation
The cyclin-dependent kinase CDK11 functions in transcription, mitotic progression, and mRNA splicing. Specifically, spliceosome activation during the B to Bact transition depends on phosphorylation of the U2 snRNP component SF3B1 by the CDK11-cyclin L-SAP30BP complex. Here, we present the structure ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-24 | PXD060582 | Pride
Cdk11-cyclin L-sap30bp 
UnknownTargeting CDK11 in Rhabdoid Tumor of the Kidney.
Not available
S-EPMC12839316 | biostudies-literature
OtherCDK11 phosphorylates SF3B1 and is essential for constitutive splicing (iCLIP)
Pre-mRNA splicing is a highly regulated process catalyzing intron excision by spliceosome. Spliceosome activation is a major control step requiring dramatic protein and RNA rearrangements leading to a catalytically active complex. Prior research has linked hyperphosphorylation of SF3B1, a subunit of...
ORGANISM(S): Homo sapiens 
2022-07-09 | GSE185811 | GEO
OtherCDK11 phosphorylates SF3B1 and is essential for constitutive splicing (4sU-seq)
Pre-mRNA splicing is a highly regulated process catalyzing intron excision by spliceosome. Spliceosome activation is a major control step requiring dramatic protein and RNA rearrangements leading to a catalytically active complex. Prior research has linked hyperphosphorylation of SF3B1, a subunit of...
ORGANISM(S): Homo sapiens 
2022-07-09 | GSE185810 | GEO
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