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ProteomicsCryo-EM structure of the CDK11-cyclin L-SAP30BP complex reveals mechanisms of CDK11 regulation
The cyclin-dependent kinase CDK11 functions in transcription, mitotic progression, and mRNA splicing. Specifically, spliceosome activation during the B to Bact transition depends on phosphorylation of the U2 snRNP component SF3B1 by the CDK11-cyclin L-SAP30BP complex. Here, we present the structure ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-24 | PXD060582 | Pride
Cdk11-cyclin L-sap30bp 
UnknownCDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing.
Not available
S-EPMC12721332 | biostudies-literature
ProteomicsCDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing – phosphopeptides dataset
Cyclin-dependent kinase 11 (CDK11) is essential for the regulation of pre-mRNA splicing via phosphorylation of the core spliceosome component SF3B1. This phosphorylation is a marker of the catalytically active spliceosomes thus it is important to identify the mechanisms that regulate CDK11 itself. H...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD062535 | Pride
Ots964 Sf3b1 Cdk7 Cdk11 Splicing Sy351 
ProteomicsCDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing – BioID dataset
Cyclin-dependent kinase 11 (CDK11) is essential for the regulation of pre-mRNA splicing via phosphorylation of the core spliceosome component SF3B1. This phosphorylation is a marker of the catalytically active spliceosomes thus it is important to identify the mechanisms that regulate CDK11 itself. H...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD068896 | Pride
Ots964 Sf3b1 Cdk7 Cdk11 Splicing Sy351 
GenomicsCDK7 regulates pre-mRNA splicing via CDK11
Cyclin-dependent kinase 11 (CDK11) is essential for the regulation of pre-mRNA splicing by phosphorylating SF3B1, a core spliceosome component. This phosphorylation is a marker of the catalytically active spliceosome, so it is important to identify the mechanisms that regulate CDK11. Herein, we repo...
ORGANISM(S): Homo sapiens 
2025-12-31 | GSE290846 | GEO
GenomicsCDK7 regulates pre-mRNA splicing via CDK11
CDK7 regulates pre-mRNA splicing via CDK11
PRJNA1230229 | ENA
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