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ProteomicsCryo-EM structure of the CDK11-cyclin L-SAP30BP complex reveals mechanisms of CDK11 regulation
The cyclin-dependent kinase CDK11 functions in transcription, mitotic progression, and mRNA splicing. Specifically, spliceosome activation during the B to Bact transition depends on phosphorylation of the U2 snRNP component SF3B1 by the CDK11-cyclin L-SAP30BP complex. Here, we present the structure ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-24 | PXD060582 | Pride
Cdk11-cyclin L-sap30bp 
TranscriptomicsCdk11-Cyclin L controls the assembly of the RNA polymerase II Mediator
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-11 | E-GEOD-37962 | biostudies-arrayexpress
TranscriptomicsCdk11-Cyclin L controls the assembly of the RNA polymerase II Mediator [expression]
The L-Mediator is a general co-activator of RNA Polymerase II transcription and is formed by the reversible association of the S-Mediator and the kinase module harbouring Cdk8. We describe the Cdk11-Lcp1 complex and show that its inactivation alter the global expression profiles in a very similar wa...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-11 | E-GEOD-37960 | biostudies-arrayexpress
TranscriptomicsCdk11-Cyclin L controls the assembly of the RNA polymerase II Mediator [ChIP-chip]
The L-Mediator is a general co-activator of RNA Polymerase II transcription and is formed by the reversible association of the S-Mediator and the kinase module harbouring Cdk8. We describe the Cdk11-Lcp1 complex and show that its inactivation alter the global expression profiles in a very similar wa...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-11 | E-GEOD-37961 | biostudies-arrayexpress
UnknownA cyclin-dependent kinase, CDK11/p58, represses cap-dependent translation during mitosis.
Not available
S-EPMC7599166 | biostudies-literature
UnknownCyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells.
Not available
S-EPMC4128631 | biostudies-literature
UnknownThe cyclin-dependent kinase PITSLRE/CDK11 is required for successful autophagy.
Not available
S-EPMC3242795 | biostudies-literature
TranscriptomicsTranscription profiling by array of human non-activated MM6 cells with cyclin T1 knockdown
Cyclin T1-dependent genes in LPS-activated MM6 cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II ...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10738 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human parental MM6 cell response to lipoloysaccharide and phorbal ester
Parental MM6 cells, as an additional control, were treated with LPS and PMA. Genes affected by the treatments were identified. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One cr...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10739 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human PMA-activated Jurkat cells
Cyclin T1-dependent genes in activated Jurkat cells. HIV-1 is dependent upon cellular co-factors to mediate its replication cycle in CD4+ T cells and macrophages, the two major cell types infected by the virus in vivo. One critical co-factor is Cyclin T1, a subunit of a general RNA polymerase II el...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-10232 | biostudies-arrayexpress
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