Sort   by:  
 Page size 
TranscriptomicsCdk11-Cyclin L controls the assembly of the RNA polymerase II Mediator [ChIP-chip]
The L-Mediator is a general co-activator of RNA Polymerase II transcription and is formed by the reversible association of the S-Mediator and the kinase module harbouring Cdk8. We describe the Cdk11-Lcp1 complex and show that its inactivation alter the global expression profiles in a very similar wa...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-11 | E-GEOD-37961 | biostudies-arrayexpress
TranscriptomicsCdk11-Cyclin L controls the assembly of the RNA polymerase II Mediator [expression]
The L-Mediator is a general co-activator of RNA Polymerase II transcription and is formed by the reversible association of the S-Mediator and the kinase module harbouring Cdk8. We describe the Cdk11-Lcp1 complex and show that its inactivation alter the global expression profiles in a very similar wa...
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-11 | E-GEOD-37960 | biostudies-arrayexpress
ProteomicsA CDK11-dependent RNA polymerase II pause-checkpoint precedes CDK9-mediated transition to transcriptional elongation
Controlled gene expression is achieved through the intricate regulation of Pol II progression through transcription-cycle checkpoints. While the contribution of CDK9 for Pol II pause-release is well established, the requirement for other CDKs has not been fully elucidated. Here we propose a new role...
ORGANISM(S): Homo sapiens (Human) 
2025-09-09 | PXD066230 | Pride
Cdk11 Transcription Pause-release Leukaemia 
ProteomicsCryo-EM structure of the CDK11-cyclin L-SAP30BP complex reveals mechanisms of CDK11 regulation
The cyclin-dependent kinase CDK11 functions in transcription, mitotic progression, and mRNA splicing. Specifically, spliceosome activation during the B to Bact transition depends on phosphorylation of the U2 snRNP component SF3B1 by the CDK11-cyclin L-SAP30BP complex. Here, we present the structure ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-24 | PXD060582 | Pride
Cdk11-cyclin L-sap30bp 
TranscriptomicsCdk11-Cyclin L controls the assembly of the RNA polymerase II Mediator
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2014-07-11 | E-GEOD-37962 | biostudies-arrayexpress
ProteomicsCDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing – phosphopeptides dataset
Cyclin-dependent kinase 11 (CDK11) is essential for the regulation of pre-mRNA splicing via phosphorylation of the core spliceosome component SF3B1. This phosphorylation is a marker of the catalytically active spliceosomes thus it is important to identify the mechanisms that regulate CDK11 itself. H...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD062535 | Pride
Ots964 Sf3b1 Cdk7 Cdk11 Splicing Sy351 
ProteomicsCDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing – BioID dataset
Cyclin-dependent kinase 11 (CDK11) is essential for the regulation of pre-mRNA splicing via phosphorylation of the core spliceosome component SF3B1. This phosphorylation is a marker of the catalytically active spliceosomes thus it is important to identify the mechanisms that regulate CDK11 itself. H...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD068896 | Pride
Ots964 Sf3b1 Cdk7 Cdk11 Splicing Sy351 
GenomicsCDK7 regulates pre-mRNA splicing via CDK11
CDK7 regulates pre-mRNA splicing via CDK11
PRJNA1230229 | ENA
ProteomicsOn-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions
The cyclin-dependent kinase CDK11 is an understudied kinase that has been the subject of conflicting reports regarding its function in cancer. Here, we combine genetic and pharmacological approaches to demonstrate that CDK11 is a critical regulator of cancer cell survival that is required for RNA sp...
ORGANISM(S): Homo sapiens (Human) 
2026-08-07 | PXD079783 | Pride
Kinase inhibitor Ots964 Splicing Cdk11 Cell cycle 
ProteomicsCDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
RNA splicing, the process of intron removal from pre-mRNA, is essential for the regulation of gene expression. It is controlled by the spliceosome, a megadalton RNA-protein complex that assembles de novo on each pre-mRNA intron via an ordered assembly of intermediate complexes. Spliceosome activatio...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-07-09 | MSV000089855 | MassIVE
Sort   by:  
 Page size