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MetabolomicsFbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells
Not available
ORGANISM(S): Mus musculus 
ST001986 | MetabolomicsWorkbench
TranscriptomicsPrimary murine embryonic fibroblasts (MEFs): Cdk7 wild type versus Cdk7 KO
Transcriptional profiling of primary Cdk7lox/lox MEFs comparing Adeno-Cre vs Adeno-GFP infected controls. Samples were obtained 7 days after the Adeno-Cre mediated elimination of Cdk7. Goal was to determine the effects of Cdk7 elimination on RNA polII-mediated transcription. Two-condition experiment...
ORGANISM(S): Mus musculus 
2012-04-17 | E-GEOD-36050 | biostudies-arrayexpress
GenomicsTargeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (ChIP-Seq)
Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and patholo...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-50622 | biostudies-arrayexpress
TranscriptomicsCDK7-dependent Transcriptional Addiction in Triple-Negative Breast Cancer (Microarray)
Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that exhibits extremely high levels of genetic complexity and yet a relatively uniform transcriptional program. We postulate that TNBC might be highly dependent on uninterrupted transcription of a key set of genes with...
ORGANISM(S): Homo sapiens 
2015-09-24 | E-GEOD-69106 | biostudies-arrayexpress
ProteomicsCDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing – phosphopeptides dataset
Cyclin-dependent kinase 11 (CDK11) is essential for the regulation of pre-mRNA splicing via phosphorylation of the core spliceosome component SF3B1. This phosphorylation is a marker of the catalytically active spliceosomes thus it is important to identify the mechanisms that regulate CDK11 itself. H...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD062535 | Pride
Ots964 Sf3b1 Cdk7 Cdk11 Splicing Sy351 
ProteomicsCDK7-CDK11 axis in spliceosome regulation and pre-mRNA splicing – BioID dataset
Cyclin-dependent kinase 11 (CDK11) is essential for the regulation of pre-mRNA splicing via phosphorylation of the core spliceosome component SF3B1. This phosphorylation is a marker of the catalytically active spliceosomes thus it is important to identify the mechanisms that regulate CDK11 itself. H...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD068896 | Pride
Ots964 Sf3b1 Cdk7 Cdk11 Splicing Sy351 
TranscriptomicsTargeting transcriptional dependencies in cancer using a covalent CDK7 inhibitor (expression)
Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and patholo...
ORGANISM(S): Homo sapiens 
2014-06-22 | E-GEOD-50624 | biostudies-arrayexpress
GenomicsCDK7-dependent Transcriptional Addition in Basal-like Breast Cancer
Basal-like breast cancer (BBC) is a highly aggressive form of breast cancer that exhibits extremely high levels of genetic complexity and yet a relatively uniform transcriptional program. We postulate that BBC might be highly dependent on uninterrupted transcription of a key set of genes within this...
ORGANISM(S): Homo sapiens 
2015-01-23 | E-GEOD-65201 | biostudies-arrayexpress
ProteomicsAn integrative multi-omics approach uncovers the regulatory role of Cdk7 and Cdk4 in autophagy induced by silica nanoparticles
The abnormal induction of macroautophagy/autophagy, a highly conserved lysosome-based degradation pathway, has been postulated as a major toxicity of nanomaterials, whereas little is known on the exact molecular mechanisms. Here, we treated mammalian cells with 16 nm silica nanoparticles (SiNPs), co...
ORGANISM(S): Rattus Norvegicus 
2019-12-01 | PXD012196 |
TranscriptomicsTargeting of Super-Enhancer-Associated Oncogenic Transcription in MYCN-driven tumor cells by CDK7 inhibition [Gene Expression]
Global gene expression after CDK7 inhibition by THZ1 Global gene expression after genetic knockdown or overexpression of MYCN
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-62724 | biostudies-arrayexpress
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