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TranscriptomicsAI-2-dependent gene regulation in Staphylococcus epidermidis
Autoinducer 2 (AI-2), a widespread by-product of the LuxS-catalyzed S-ribosylhomocysteine cleavage reaction in the activated methyl cycle, has been suggested to serve as an intra- and interspecies signaling molecule, but in many bacteria AI-2 control of gene expression is not completely understood. ...
ORGANISM(S): Staphylococcus epidermidis 
2008-10-10 | E-GEOD-9427 | biostudies-arrayexpress
TranscriptomicsRole of the accessory gene regulator agr in community-associated MRSA pathogenesis
The success of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) as pathogens is due to a combination of antibiotic resistance with high virulence. However, evolution of the exceptional virulence potential of CA-MRSA is not understood. Our previous study indicated that diffe...
ORGANISM(S): Staphylococcus aureus 
2011-03-29 | E-GEOD-18793 | biostudies-arrayexpress
TranscriptomicsThe antimicrobial peptide-sensing system aps of Staphylococcus aureus
Staphylococcus aureus is a leading cause of hospital-associated infections. In addition, highly virulent strains of methicillin-resistant S. aureus (MRSA) are currently spreading outside health care settings. Survival in the human host is largely defined by the ability of S. aureus to resist mechani...
ORGANISM(S): Staphylococcus aureus 
2008-04-06 | E-GEOD-8400 | biostudies-arrayexpress
TranscriptomicsA Gram-positive three-component antimicrobial peptide-sensing system
To survive during colonization or infection of the human body, microorganisms must defeat antimicrobial peptides, which represent a key component of innate host defense in phagocytes and on epithelia. However, is not known how the clinically important group of Gram-positive bacteria sense antimicrob...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-26 | E-GEOD-7163 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Wild Type and â–³Rsp MRSA Transcriptomes
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of gene regulon. The goal of this study is to investigate the genes regulated by Rsp in MRSA BD02-25 Methods: mRNA profiles of wild-type (WT) and Rsp knockout (â–³Rsp) MRSA at mid-logarithmic growth phase (4h) were g...
ORGANISM(S): Staphylococcus aureus 
2016-07-04 | E-GEOD-67344 | biostudies-arrayexpress
TranscriptomicsSarZ is a key regulator of biofilm formation and virulence in Staphylococcus epidermidis
Biofilm-associated infection by the leading nosocomial pathogen Staphylococcus epidermidis is a major problem for the public health system. Here we used an especially discriminatory, two-step screen to discover key biofilm factors. We identified the transcriptional regulator and SarA paralog SarZ as...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-25 | E-GEOD-8523 | biostudies-arrayexpress
TranscriptomicsEvolution of virulence control by the staphylococcal agr quorum-sensing regulator
The Staphylococcus aureus accessory gene regulator (agr) is a prototype quorum-sensing system in Gram-positive bacteria and a paradigmatic example of gene regulation by a small regulatory RNA, RNAIII. Using genome-wide transcriptional profiling in the community-associated methicillin-resistant (CA-M...
ORGANISM(S): Staphylococcus aureus 
2010-05-14 | E-GEOD-10165 | biostudies-arrayexpress
UnknownGenotypes selected for early and late avian lay date differ in their phenotype, but not fitness, in the wild.
Not available
S-EPMC10246905 | biostudies-literature
TranscriptomicsGenome-scale analysis of Staphylococcus aureus reveals host-specific diversification of the core genome.
Staphylococcus aureus causes disease in humans and a wide array of animals. Of note, S. aureus mastitis of ruminants, including cows, sheep and goats, results in major economic losses worldwide. Extensive variation in genome content exists among S. aureus pathogenic clones. However, the genomic vari...
ORGANISM(S): Staphylococcus aureus 
2008-11-18 | E-GEOD-10187 | biostudies-arrayexpress
TranscriptomicsA point mutation in the agr locus caused previously reported phenotypes in Staphylococcus aureus pneumonia
The role of Pantonâ??Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S.aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by Labandeiraâ??Rey et al. (Scien...
ORGANISM(S): Staphylococcus aureus 
2010-05-16 | E-GEOD-14394 | biostudies-arrayexpress
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