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ProteomicsEndothelial OTUD1 promotes Ang II-induced vascular remodeling by deubiquitinating SMAD3
Understanding the molecular mechanisms of pathological vascular remodeling is important for treating cardiovascular diseases and complications. Recent studies have highlighted a role of deubiquitinases in vascular pathophysiology. In this study, we investigated the role of a deubiquitinase, OTUD1, i...
ORGANISM(S): Homo sapiens (Human) 
2022-12-24 | PXD037926 | Pride
Huvec  lc-ms/ms 
ProteomicsThe deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
Serum monoclonal immunoglobulin (Ig) is the main diagnostic factor for patients with multiple myeloma (MM), however its prognostic potential remains unclear. On a large MM patient cohort (n=4146), we observe no correlation between serum Ig levels and patient survival, while amount of intracellular I...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037309 | Pride
Multiple myeloma Deubiquitinase otud1 
ProteomicsAnalysis of activated CD4T cells and OTUD1-deficient CD4T cells reveals novel target proteins and related signaling pathway affected by OTUD1
The goals of the study are to compare differently expressed proteins in activated CD4T and OTUD1-deficient CD4T cells. Proteomics was performed with activated CD4T and OTUD1-deficient CD4T cells (n = 3 for each group) to identify the differently expressed proteins and related signaling pathway affe...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-18 | PXD036217 | Pride
Proteomics Activated cd4t Signaling pathway Otud1 
GenomicsTranscriptome analysis of control and OTUD1 knockout T24 Cells
Transcriptome analysis of control and OTUD1 knockout T24 Cells
PRJNA899560 | ENA
GenomicsTranscriptome analysis of control and OTUD1 knockout SKOV3 Cells
Transcriptome analysis of control and OTUD1 knockout SKOV3 Cells
PRJNA973961 | ENA
GenomicsEndothelial OTUD1 promotes Ang II-induced vascular remodeling by deubiquitinating SMAD3
Endothelial OTUD1 promotes Ang II-induced vascular remodeling by deubiquitinating SMAD3
PRJNA898372 | ENA
GenomicsThe deubiquitinase OTUD1 attenuates periodontal inflammation by restricting neutrophil protein transport
The deubiquitinase OTUD1 attenuates periodontal inflammation by restricting neutrophil protein transport
PRJNA894293 | ENA
GenomicsOTUD1 aggravates pathological cardiac hypertrophy through activation of PGAM5-ASK1 signaling pathways
OTUD1 aggravates pathological cardiac hypertrophy through activation of PGAM5-ASK1 signaling pathways
PRJNA1010134 | ENA
UnknownBreast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7.
Not available
S-EPMC5727433 | biostudies-literature
TranscriptomicsTranscriptome analysis of control and OTUD1 knockout T24 Cells
We have confirmed that OTUD1 interacted directly with Akt and inhibited Akt phosphorylation. To investigate the exact mechanism of OTUD1 in the regulation of Akt signaling pathway, we established T24 cells with stable OTUD1 depletion by using sgRNA.
ORGANISM(S): Homo sapiens 
2022-12-23 | GSE217570 | GEO
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