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ProteomicsOTUD5 complex mass spectrometry
DUBs are involved in various pathways and signalling networks by pairing with E3 ubiquitin ligases in protein complexes. In order to test whether OTUD5 associates with an E3 ubiquitin ligase to regulate cell proliferation, the stable Flag-OTUD5/Hep3B cell line was established by transfecting Hep3B c...
ORGANISM(S): Homo sapiens (Human) 
2020-09-11 | PXD019907 | Pride
Otud5 Protein complex 
GenomicsWhole-transcriptome analysis using RNA sequencing in OTUD5-wild type, OTUD5-null, and GDC0349-treated HEK293 cells
Whole-transcriptome analysis using RNA sequencing in OTUD5-wild type, OTUD5-null, and GDC0349-treated HEK293 cells
PRJNA557353 | ENA
TranscriptomicsWhole-transcriptome analysis using RNA sequencing in OTUD5-wild type, OTUD5-null, and GDC0349-treated HEK293 cells
Whole-transcriptome analysis was performed on RNA from OTUD5-wild type, OTUD5-null, and GDC0349-treated HEK293 cells to identify the cellular processes regulated by OTUD5 and mTOR simultaneously.
ORGANISM(S): Homo sapiens 
2021-03-18 | GSE135078 | GEO
GenomicsAutophagy of OTUD5 Destabilizes GPX4 to Confer Ferroptosis-Dependent Kidney Injury
Autophagy of OTUD5 Destabilizes GPX4 to Confer Ferroptosis-Dependent Kidney Injury
PRJNA1022413 | ENA
UnknownOTUD5 limits replication fork instability by organizing chromatin remodelers.
Not available
S-EPMC10602872 | biostudies-literature
UnknownThe Regulation and Double-Edged Roles of the Deubiquitinase OTUD5.
Not available
S-EPMC10136533 | biostudies-literature
UnknownThe OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin.
Not available
S-EPMC6344881 | biostudies-literature
TranscriptomicsAutophagy of OTUD5 Destabilizes GPX4 to Confer Ferroptosis-Dependent Kidney Injury
Ferroptosis is an iron-dependent programmed cell death associated with severe kidney diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial distribution of renal GPX4-mediated ferroptosis and the molecular events causing GPX4 reduction during ischemia-reperfusion (I/R) r...
ORGANISM(S): Mus musculus 
2023-11-29 | GSE244330 | GEO
ProteomicsUbiquitination analysis of OTUD5
TMT quantification of UBR5 knockdown HT1080 cells. Label-free quantification of OTUD5-interacting proteins.
ORGANISM(S): Homo sapiens (Human) 
2025-02-20 | PXD054556 | Pride
Human ht1080 cells Hek293t cells Ubiquitin 
UnknownDeubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways.
Not available
S-EPMC7937674 | biostudies-literature
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