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Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. Here we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of m...
ORGANISM(S): Homo sapiens 
RNA expression profiles from 12 (twelve) osteosarcomas arisen from p53+/- mouse were compared with a mc3T3 osteoblast control, and a rhabdomyosarcoma expression profile which was from a mouse with the same genetic background. Experiment Overall Design: Total RNA was extracted from 12 osteosarcomas a...
ORGANISM(S): Mus musculus 
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