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TranscriptomicsA Pathobiological Role of the Insulin Receptor in CLL.
Purpose: The chromosomal deletion 11q affects biology and clinical outcome in CLL but del11q-deregulated genes remain incompletely characterized. Results: We have identified differential expression of the insulin receptor (INSR) in CLL, including high-level INSR expression in the majority of CLL wi...
ORGANISM(S): Homo sapiens 
2011-05-05 | E-GEOD-26526 | biostudies-arrayexpress
TranscriptomicsClonal evolution and devolution following chemotherapy in adult acute myelogenous leukemia
The frequent occurrence of persistent or relapsed disease following induction chemotherapy in AML necessitates a better understanding of the clonal relationship of AML in various disease phases. In this study, we employed SNP 6.0 array-based genomic profiling of acquired copy number aberrations (aCN...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-41646 | biostudies-arrayexpress
TranscriptomicsAcquired genomic copy number aberrations and survival in chronic lymphocytic leukemia
Genomic aberrations are of predominant importance to the biology and clinical outcome of patients with chronic lymphocytic leukemia (CLL), and FISH-based genomic risk classifications are routinely used in clinical decision making in CLL. One of the known limitations of CLL FISH is the inability to ...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-30777 | biostudies-arrayexpress
TranscriptomicsClonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia
The identification of gene mutation and structural genomic aberrations that are critically involved in CLL pathogenesis is still evolving. One may postulate that genomic driver lesions with effects on CLL proliferation, apoptosis thresholds, or chemotherapy resistance should increase in frequency o...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-45565 | biostudies-arrayexpress
TranscriptomicsAnalysis of the coding exome of follicular lymphoma
Follicular lymphoma (FL) constitutes the second most common non-Hodgkin lymphoma in the Western world. FL carries characteristic recurrent structural genomic aberrations. However, information regarding the coding genome in FL is still evolving. Here, we describe the results of massively parallel ex...
ORGANISM(S): Homo sapiens 
2014-01-17 | E-GEOD-50973 | biostudies-arrayexpress
TranscriptomicsNF1 inactivation in adult acute myelogenous leukemia
Purpose: This study was conducted to identify novel genes with importance to the biology of adult acute myelogenous leukemia (AML). Conclusions: NF1 null states are present in 7/95=7% of adult AML and delineate a disease subset that could be preferentially targeted by Ras or mTOR-directed therapeut...
ORGANISM(S): Homo sapiens 
2010-12-02 | E-GEOD-21107 | biostudies-arrayexpress
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