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ProteomicsMouse bone marrow-derived macrophages (BMDMs) loaded with atherogenic LDL
While aging is well established as an important risk factor for the development and progression of atherosclerosis, the underlying molecular mechanisms of this relationship remain poorly defined, and its role in atherosclerosis regression is unknown. We investigated the response of bone marrow-deriv...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD054290 | Pride
Atherosclerosis Murine Ageing Primary cells 
ProteomicsORP6 regulates astrocytic cholesterol metabolism and brain Aβ deposition
The mammalian brain is the most cholesterol-rich organ of the body, requiring in situ de novo cholesterol synthesis to meet this demand. Defects in brain cholesterol homeostasis are implicated in cognitive deficits related to aging and in neurodegenerative diseases, such as Alzheimer’s Disease (AD)....
ORGANISM(S): Mus musculus (Mouse) 
2025-09-29 | PXD035149 | Pride
Mouse Brain Label-free Hplc-esi-ms/ms 
ProteomicsIdentification of Novel Lipid Droplet Factors that Regulate Lipophagy and Cholesterol Efflux in Macrophage Foam Cells
Macrophage autophagy is a highly anti-atherogenic process that promotes the catabolism of cytosolic lipid droplets (LDs) to maintain cellular lipid homeostasis. Selective autophagy relies on tags such as ubiquitin and a set of selectivity factors including selective autophagy receptors (SARs) to lab...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD017511 | Pride
Human Lipid droplet Macrophage foam cell Lc-ms/ms 
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