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MetabolomicsThe patatin-like protein PlpD forms novel structurally dynamic homodimers in the Pseudomonas aeruginosa outer membrane

Members of the Omp85 superfamily of outer membrane proteins (OMPs) found in Gram-negative bacteria, mitochondria and chloroplasts are characterized by a distinctive 16-stranded β-barrel transmembrane domain and at least one periplasmic POTRA domain. All previously studied Omp85 proteins promote c...

2025-12-08 | MTBLS9803 | MetaboLights
ProteomicsLocalisation of outer membrane proteins in Treponema denticola by quantitative proteome analyses of outer membrane vesicles and cellular fractions
The identification and localisation of outer membrane proteins (Omps) and lipoproteins in pathogenic treponemes such as T. denticola (periodontitis) and T. pallidum (syphilis) has been challenging largely due to the structural uniqueness of their outer membranes (OM), the high abundance of inner mem...
ORGANISM(S): Treponema denticola ATCC 35405 
2019-02-20 | PXD011495 | Pride
Treponema denticola Localization Outer membrane vesicles Bacterial lipoproteins Maxquant Outer membrane proteins Orbitrap 
ProteomicsA Conformationally Arrested Peptidomimetic Antibiotic Disrupts Selectively the Outer Membrane in Escherichia coli
Using a shotgun proteomics approach, the expressed proteome of total membrane fractions of Escherichia coli ATCC25922 cells was analyzed under i) normal growth, and ii) treatment with the novel peptidomimetic JB-95 (a structurally arrested cyclic peptide). By selectively disrupturing the outer membr...
ORGANISM(S): Escherichia coli 
2015-12-07 | PXD002588 | Pride
Shotgun proteomics Novel antibiotic Arrested cyclic peptide Om rupture New moa E. coli Total membrane fraction 
ProteomicsOuter membrane vesicle and outer membrane of Haemophilus influenzae Rd KW20, Rd ∆yrbE and Rd ∆vacJ
Bacterial outer membrane vesicles (OMVs) have important biological roles in pathogenesis and intercellular interactions, but a general mechanism of OMV formation is lacking. Here we show that the VacJ/Yrb ABC transport system, a proposed phospholipid (PL) transporter, is involved in OMV formation. D...
ORGANISM(S): Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 
2016-01-27 | PXD003249 | Pride
Mla pathway Omv Haemophilus influenzae Retrograde lipid trafficking system Om 
ProteomicsThanatin Targets the Inter-Membrane Protein Complex Required for Lipopolysaccharide Transport in Escherichia coli
With the increasing resistance of many Gram-negative bacteria to existing classes of antibiotics, identifying new paradigms in antimicrobial discovery is an important research priority. Of special interest here are the proteins required for the biogenesis of the symmetric Gram-negative bacterial out...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2020-02-04 | MSV000084897 | MassIVE
ProteomicsOuter membrane utilisomes mediate oligosaccharide uptake in gut Bacteroidetes
Bacteroidetes are abundant members of the human microbiota, and species occupying the distal gut are capable of utilising a myriad of diet- and host-derived glycans. Transport of glycans across the outer membrane (OM) of these bacteria is mediated by SusCD protein complexes. Additionally, cell surfa...
ORGANISM(S): Bacteroides thetaiotaomicron Bacteria 
2023-06-19 | PXD034863 | Pride
Outer membrane proteome Microbiota Glycan utilisation Gut bacteroidetes 
ProteomicsUnderstanding the interaction of SurA and BAM in the outer membrane of E. coli
The outer membrane (OM) is a formidable barrier that protects Gram-negative bacteria against environmental threats. The correct folding and insertion of outer membrane proteins (OMPs) into the OM requires the essential OM-embedded β-barrel assembly machinery (BAM), a heptameric protein complex in E....
ORGANISM(S): Escherichia coli 
2024-10-01 | PXD046606 | Pride
Bam E coli Sura Outer membrane 
ProteomicsStructure of an essential inner membrane protein-LPS complex identifies a novel anti-microbial peptide
Lipopolysaccharide (LPS) resides in the outer membrane (OM) of Gram-negative bacteria where it is responsible for barrier function and immune modulation. LPS is the target of polymyxins, last-resort antibiotics whose clinical use is threatened by increasing resistance. Steps in LPS biogenesis are ...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2019-05-08 | MSV000083754 | MassIVE
ProteomicsIdentification of the effect of a CRISPR interference knockdown of Borrelia burgdorferi strain B31 BB0838, a outer membrane lipoprotein flippase candidate, on surface lipoprotein secretion using Multidimensional Protein Identification Technology.
To identify the effect of a CRISPR interference knockdown of Borrelia burgdorferi strain B31 BB0838, a outer membrane lipoprotein flippase candidate, on surface lipoprotein secretion using Multidimensional Protein Identification Technology.
ORGANISM(S): Borrelia Burgdorferi B31 (ncbitaxon:224326) 
2022-07-27 | MSV000089990 | MassIVE
TranscriptomicsBamA self-insertion drives inner-to-outer membrane remodelling in diderm Firmicutes
Exclusive to Firmicutes, endospore formation is a complex process that results in the release of a mature spore after the mother cell lyses. The spore is protected by multiple layers, including inner and outer spore membranes (IsM and OsM), both originating from the mother cell's inner membrane (IM)...
ORGANISM(S): Acetonema longum 
2025-09-06 | GSE306945 | GEO
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