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TranscriptomicsRetinoic acid signaling coordinates the behavior of multiple cell lineages during cardiac outflow morphogenesis
Retinoic acid (RA), the bioactive derivative of vitamin A, is essential for vertebrate heart development. Both excess and reduced RA signaling lead to cardiovascular malformations, particularly affecting the cardiac outflow tract (OFT). The cellular mechanisms underlying the effects of RA signaling ...
ORGANISM(S): Mus musculus 
2015-12-21 | E-GEOD-64556 | biostudies-arrayexpress
TranscriptomicsAnterior Heart Field (AHF)-conditional Mef2c Knockout
We have performed conditional inactivation of mef2c in the anterior heart field (AHF) of mice and observed a phenotypic spectrum of outflow tract anomalies in the conditional mutant hearts. In an effort to identify misregulated genes in the outflow tracts of the mutants, we have performed RNA-Seq o...
ORGANISM(S): Mus musculus 
2016-04-05 | E-GEOD-68147 | biostudies-arrayexpress
TranscriptomicsConstitutively active RhoA (RhoAV14) expression and regulation of acqeous humor outflow dynamics
Impaired drainage of aqueous humor through the trabecular meshwork (TM) culminating in increased intraocular pressure is a major risk factor for glaucoma, a leading cause of blindness worldwide. Regulation of aqueous humor drainage through the TM, however, is poorly understood. The role of RhoA GTPa...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-9288 | biostudies-arrayexpress
ProteomicsIncreased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition
Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease. However, the progressive detrimental remodeling processes that relate altered blood flow...
ORGANISM(S): Gallus Gallus (ncbitaxon:9031) 
2019-07-17 | MSV000084103 | MassIVE
TranscriptomicsExpression data from from the E9.25 hearts of mouse embryos
Congenital heart defects (CHDs) occur in 0.5–1% of live births, yet the underlying genetic etiology remains mostly unknown. Recently, a new source of myocardial cells, namely the second heart field (SHF), was discovered in the splanchnic mesoderm. Abnormal development of the SHF leads to a spectrum ...
ORGANISM(S): Mus musculus 
2011-03-26 | E-GEOD-28186 | biostudies-arrayexpress
UnknownIsolation and characterization of novel primary cells from the human distal outflow pathway.
Not available
S-EPMC7890058 | biostudies-literature
UnknownPediatric postoperative cerebellar cognitive affective syndrome follows outflow pathway lesions.
Not available
S-EPMC6815203 | biostudies-literature
UnknownEvaluation of neural innervation in the human conventional outflow pathway distal to Schlemm's canal.
Not available
S-EPMC10493174 | biostudies-literature
UnknownReduced Aqueous Humor Outflow Pathway Arborization in Childhood Glaucoma Eyes.
Not available
S-EPMC10981159 | biostudies-literature
UnknownA Histomorphometric and Computational Investigation of the Stabilizing Role of Pectinate Ligaments in the Aqueous Outflow Pathway.
Not available
S-EPMC10614930 | biostudies-literature
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