Sort   by:  
 Page size 
MetabolomicsDistinct metabolic responses of an ovarian cancer stem cell line

Background

Cancer metabolism is emerging as an important focus area in cancer research. However, the in vitro cell culture conditions under which much cellular metabolism research is performed differ drastically from in vivo tumor conditions, which are characterized by variations in the leve...
2021-11-05 | MTBLS150 | MetaboLights
TranscriptomicsExpression data from TGF-beta-treated human ovarian fibroblasts
Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Ovarian cancer cells are known to have diminished response to TGF-beta, but it remains unclear whether TGF-beta can modulate ovarian cancer cell growth in an indirect manner through cancer-associated fibroblasts ...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-40266 | biostudies-arrayexpress
TranscriptomicsExpression data from Versican (VCAN) protein treated ovarian cancer cell line OVCA433
Advanced ovarian cancer is the most lethal gynecologic malignancy in the United States. Currently patients are treated by surgical cytoreductive surgery with the aim of reducing tumor burden to microscopic disease followed by adjuvant combined treatment with a platinum and taxane containing chemothe...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-40241 | biostudies-arrayexpress
GenomicsDeregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - ChIPseq
PPARD and RXR genome wide binding in tumor associated macrophages from serous ovarian carcinoma was characterized.
ORGANISM(S): Homo sapiens 
2015-06-01 | E-MTAB-3166 | biostudies-arrayexpress
TranscriptomicsDeregulation of PPAR-beta/delta target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment - RNAseq
The transcriptome of serous ovarian cancer tumor associated macrophages was characterized. Additionally, their transcription response to PPARD agonists and inverse agonists in cell culture was analyzed.
ORGANISM(S): Homo sapiens 
2015-05-31 | E-MTAB-3167 | biostudies-arrayexpress
TranscriptomicsHey3Met2 human ovarian cancer cells overexpressing wild type or catalytically-dead mutant RNASET2
Hey3Met2 cells were stably transfected with plasmids encoding either wild-type RNASET2 or a catalytically dead form (whose cDNA has been previously mutagenized in the two CAS catalytic sites) or with the empty vector as a control. The control of ovarian tumorigenesis by RNASET2 occurs through modifi...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28478 | biostudies-arrayexpress
TranscriptomicsGene expression profiling after RNA interference of CXCR4 in human ovarian cancer cell line IGROV-1.
In the past three years the role of inflammatory cytokines and chemokines in tumour promotion and progression has been intensively studied. The chemokine receptor CXCR4 and its ligand CXCL12 are commonly expressed in malignant cells from primary tumours, metastases and also in malignant cell lines. ...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13763 | biostudies-arrayexpress
ProteomicsTumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites. We and others identified tumor-associated macrophages (TAM) in the ascites as promoters of metastasis-associated processes l...
ORGANISM(S): Homo sapiens (Human) 
2020-04-28 | PXD016555 | Pride
Cancer Tumor-associated macrophages Ascites High-grade serous ovarian carcinoma Tumor microenvironment 
ProteomicsHuman Ovarian Proteome - A draft map of the human ovarian proteome for tissue engineering and clinical applications
Fertility preservation research in women today is increasingly taking advantage of bioengineering techniques to develop new biomimetic materials and solutions to safeguard ovarian cell function and microenvironment in vitro and in vivo. However, available data on the human ovary are limited and fund...
ORGANISM(S): Homo sapiens (Human) 
2018-02-27 | PXD008183 | Pride
Matrisome Ovarian Proteome 
TranscriptomicsTumor repressor protein 53 and steroid hormones provide a new paradigm for ovarian cancer metastases
The functional status of the tumor repressor protein (TP53 or TRP53) is a defining feature of ovarian cancer. Mutant or null alleles of TP53 are expressed in greater than 90% of all high-grade serous adenocarcinomas. Wild type TP53 is elevated in low-grade serous adenocarcinomas in women and in our ...
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-51095 | biostudies-arrayexpress
Sort   by:  
 Page size