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TranscriptomicsTranscription profiling of F344/N rats administered with potassium bromate in the drinking water
Ozone has been proposed for water disinfection because it is more efficient than chlorine for killing microbes and results in much lower levels of carcinogenic trihalomethanes than does chlorination. Ozone leads to formation of hypobromous acid in surface waters with high bromine content and forms b...
ORGANISM(S): Rattus norvegicus 
2006-11-14 | E-TOXM-21 | biostudies-arrayexpress
UnknownThe effect of TRV027 on coagulation in COVID-19: A pilot randomized, placebo-controlled trial.
Not available
S-EPMC10952550 | biostudies-literature
MetabolomicsGNPS - Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-07-18 | MSV000092468 | GNPS
ProteomicsMetabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-07-18 | MSV000092468 | MassIVE
TranscriptomicsGlobal gene regulation during immunoglobulin class switching in human activated B cells
In this experiment we profile the B-cell transcriptional response underlying the generation of IgE-producing B-cells. Naïve human B-cells were isolated from three individuals
ORGANISM(S): Homo sapiens 
2017-07-11 | E-MTAB-4937 | biostudies-arrayexpress
UnknownA potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19.
Not available
S-EPMC8458290 | biostudies-literature
TranscriptomicsRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Recently, we defined four subtypes of pancreatic cancer that are associated with distinct histopathological characteristics and differential survival, namely, Squamous, Pancreatic Progenitor, Immunogenic, and ADEX (Bailey et al 2016, Nature). We also found that loss of CXCR2 was associated with a sw...
ORGANISM(S): Mus musculus 
2018-05-01 | E-MTAB-6620 | biostudies-arrayexpress
TranscriptomicsAge Map, Cerebellum (A)
To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged...
ORGANISM(S): Mus musculus 
2009-06-21 | E-GEOD-8409 | biostudies-arrayexpress
UnknownClinical complexity and impact of the ABC (Atrial fibrillation Better Care) pathway in patients with atrial fibrillation: a report from the ESC-EHRA EURObservational Research Programme in AF General Long-Term Registry.
Not available
S-EPMC9440492 | biostudies-literature
TranscriptomicsGenetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma
Asthma is caused by a combination of poorly understood genetic and environmental factors. We found multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P < 10-12. In independent replication stu...
ORGANISM(S): Homo sapiens 
2007-11-09 | E-GEOD-8052 | biostudies-arrayexpress
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