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MetabolomicsPKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Cells have evolved multiple strategies to survive environmental stress conditions. This includes the formation of membrane-less cytoplasmic ribonucleoprotein structures called stress granules that sequester and protect mRNAs encoding many housekeeping genes. Stress granules are not static biomolecul...
2026-06-16 | MTBLS13923 | MetaboLights
TranscriptomicsDEPS-1 promotes P granule assembly and RNA interference in C. elegans germ cells
P granules are germ-cell-specific cytoplasmic structures containing RNA and protein and required for proper germ cell development in C. elegans. A new P-granule-associated protein, DEPS-1, whose loss disrupts P granule structure and function was analysed in this study. Genome wide analysis of gene...
ORGANISM(S): Caenorhabditis elegans 
2010-05-26 | E-GEOD-9993 | biostudies-arrayexpress
TranscriptomicsCSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline
P granules in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency.  Sterility in the absence of P granules is often accompanied by the mis-expression of soma-specific proteins and the initiation of somatic differentiation in germ cells.  To investigate ...
ORGANISM(S): Caenorhabditis elegans 
2015-05-20 | E-GEOD-67954 | biostudies-arrayexpress
ProteomicsEpigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity
Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity, PPI of ZMYND11 in LNCap
ORGANISM(S): Homo Sapiens 
2024-08-28 | PXD055421 |
ProteomicsAtg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
Stress granule formation is a part of cellular homeostatic responses, with prototypical inducers being viral infections, heat shock and oxidative damage. Here we show that lysosomal damage is a previously unappreciated robust inducer of stress granule formation interlinked with mTOR inactivation dur...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000088152 | MassIVE
ProteomicsMembrane atg8ylation coordinates stress granule formation and mTOR inactivation in response to lysosomal damage
We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG) formation and that the process termed membrane atg8ylation coordinates SG formation with mTOR inactivation during lysosomal stress. SGs were induced by lysosome-damaging agents including SARS-CoV-2ORF3a, Mycobacteri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-09 | MSV000089622 | MassIVE
TranscriptomicsGene expression of cerebellar granule cell layer
We performed gene-expression analysis of mouse cerebellar granule cell layer as compared to that of Purkinje cells. DNA microarray analysis detected genes in cerebellar granule cell layer, most of which are classified into functional molecule categories. Our comparative analysis between Purkinje cel...
ORGANISM(S): Mus musculus 
2013-01-17 | E-GEOD-26750 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of P-granule-depleted or P-granule mutant gonads versus control gonads over time
The germ cells of multicellular organisms protect their developmental potential through specialized mechanisms. A shared feature of germ cells from worms to humans is the presence of non-membrane-bound ribonucleoprotein organelles called germ granules. Depletion of germ granules in Caenorhabditis el...
ORGANISM(S): Caenorhabditis elegans 
2016-12-22 | GSE92690 | GEO
TranscriptomicsTranscription profiling of mouse Primary cerebellar granule cell precursors (GCPs) cultures were prepared from P7 Bmi-1-/- or wild type to investigate the role of Bmi1 in Shh-mediated shift in gene expression levels
We investigated the role of Bmi1 in Shh-mediated shift in gene expression levels Experiment Overall Design: Primary cerebellar granule cell precursors (GCPs) cultures were prepared from P7 Bmi-1-/- or wild type mice as described before {Messer, 1977 #810}. Cells were grown in Dulbecco MEM high Gluc...
ORGANISM(S): Mus musculus 
2010-02-17 | E-GEOD-19176 | biostudies-arrayexpress
TranscriptomicsDEPS-1 promotes P granule assembly and RNA interference in C. elegans germ cells
P granules are germ-cell-specific cytoplasmic structures containing RNA and protein and required for proper germ cell development in C. elegans. A new P-granule-associated protein, DEPS-1, whose loss disrupts P granule structure and function was analysed in this study. Genome wide analysis of gene e...
ORGANISM(S): Caenorhabditis elegans 
2008-02-01 | GSE9993 | GEO
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