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MetabolomicsMicrobiota-derived p-cresol and indole metabolites mediates neurotoxic gut-brain axis dysregulation in ALS
Integrated metabolomic profiling demonstrated a marked increase in microbiota-derived metabolites, particularly along aromatic amino acid pathways. Notably, p-cresol metabolites were significantly elevated in both brain and circulation, suggesting enhanced microbial phenylalanine/tyrosine metabolism...
2026-08-21 | MTBLS14404 | MetaboLights
GenomicsRNA-seq of mouse brain tissue after exposure to p-cresol sulfate
RNA-seq of mouse brain tissue after exposure to p-cresol sulfate
PRJEB57411 | ENA
TranscriptomicsRNA-seq of mouse brain tissue after exposure to p-cresol sulfate
In vivo work done to determine how p-cresol glucuronide (pCS) affects integrity of the blood-brain barrier. Wild-type male C57Bl/6 mice were injected with saline or pCS, and killed 2 h after injection. Mice were transcardially perfused with 0.9% saline at 4 °C to remove circulating blood, and brains...
ORGANISM(S): Mus musculus 
2022-12-29 | E-MTAB-12326 | biostudies-arrayexpress
UnknownResults of the HEMO Study suggest that p-cresol sulfate and indoxyl sulfate are not associated with cardiovascular outcomes.
Not available
S-EPMC5696072 | biostudies-literature
UnknownEffects of p-Cresol on Oxidative Stress, Glutathione Depletion, and Necrosis in HepaRG Cells: Comparisons to Other Uremic Toxins and the Role of p-Cresol Glucuronide Formation.
Not available
S-EPMC8228354 | biostudies-literature
UnknownThe fecal microbiome and serum concentrations of indoxyl sulfate and p-cresol sulfate in cats with chronic kidney disease.
Not available
S-EPMC6430892 | biostudies-literature
Unknownp-Cresol Sulfate Is a Sensitive Urinary Marker of Fecal Microbiota Transplantation and Antibiotics Treatments in Human Patients and Mouse Models.
Not available
S-EPMC10572327 | biostudies-literature
Unknownp-Cresol and cardiovascular risk in mild-to-moderate kidney disease.
Not available
S-EPMC2893077 | biostudies-literature
UnknownMetabolism, Protein Binding, and Renal Clearance of Microbiota-Derived p-Cresol in Patients with CKD.
Not available
S-EPMC4934829 | biostudies-literature
UnknownPreliminary evaluation of fecal fatty acid concentrations in cats with chronic kidney disease and correlation with indoxyl sulfate and p-cresol sulfate.
Not available
S-EPMC6979089 | biostudies-literature
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