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GenomicsGenome-wide analysis of RB and p130 binding in human diploid fibroblasts
The action of RB as a tumor suppressor has been difficult to define, in part, due to the redundancy of the related proteins p107 and p130. By coupling advanced RNAi technology with a genome wide analysis of gene expression and RB chromatin binding, we identified a unique and specific activity of RB ...
ORGANISM(S): Homo sapiens 
2010-01-15 | E-GEOD-19898 | biostudies-arrayexpress
GenomicsDesulfosporosinus nitroreducens strain:P130
Desulfosporosinus nitroreducens strain:P130 Genome sequencing and assembly
PRJNA838811 | ENA
TranscriptomicsTranscription profiling of mouse epidermis from Rb(F19/F19)K14cre;Rbl2-/- (pRb-;p130-) mutants to analyse functional redundancies between retinoblastoma family members
The epidermal-specific ablation of Rb gene leads to increased proliferation, aberrant differentiation, and the disengagement of these processes in vivo and in vitro. These differences in phenotype are more severe with the loss of p107, demonstrating the functional compensation between pRb and p107. ...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9562 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human T98G cells during cell cycle in T98G
The mammalian Retinoblastoma (RB) family including pRB, p107, and p130 represses E2F target genes through mechanisms that are not fully understood. In D. melanogaster, RB-dependent repression is mediated in part by the multisubunit protein complex Drosophila RBF, E2F, and Myb (dREAM) that contains h...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8537 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human IMR90 cells after RNAi suppression of RB, p107 or p130 using in growing, quiescent or ras-induced senescent IMR90 cells
The action of RB as a tumor suppressor has been difficult to define, in part, due to the redundancy of the related proteins p107 and p130. By coupling advanced RNAi technology to suppress RB, p107 or p130 with a genome wide analysis of gene expression in growing, quiescent or ras-senescent cells, we...
ORGANISM(S): Homo sapiens 
2010-01-23 | E-GEOD-19864 | biostudies-arrayexpress
ProteomicsThe E2F4/p130 repressor complex cooperates with oncogenic Np73 to promote cell survival
Tumor suppressor p53 and its related proteins, p63 and p73, can be synthesized as multiple isoforms lacking part of the N- or C-terminal regions. Specifically, high expression of the Np73 isoform is notoriously associated with poor prognosis in cancer. Here, we have performed proteomics analysis of ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-28 | PXD022947 | Pride
Cellular transformation E2f4 np73 Gene expression Protein-protein interactions P53 
UnknownCell cycle-dependent acetylation of Rb2/p130 in NIH3T3 cells.
Not available
S-EPMC3007177 | biostudies-literature
Unknownp27Kip1 and p130 cooperate to regulate hematopoietic cell proliferation in vivo.
Not available
S-EPMC1592787 | biostudies-literature
UnknownInduction of Wnt/β-catenin signaling in mouse mesenchymal stem cells is associated with activation of the p130 and E2f4 and formation of the p130/Gsk3β/β-catenin complex.
Not available
S-EPMC3280596 | biostudies-literature
UnknownPromoter Methylation Status Modulate the Expression of Tumor Suppressor (RbL2/p130) Gene in Breast Cancer.
Not available
S-EPMC4536218 | biostudies-literature
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