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TranscriptomicsTranscription profiling of E2F4 double knockout mice and heterozygous littermates
We considered the possibility that removal of E2F4, as a key regulator of cellular quiescence, would cause systemic perturbations in the expression of E2F4 bound genes involved in cell cycle and proliferation. To test whether these pertubrations were reflected in the adult tissues' gene expression p...
ORGANISM(S): Mus musculus 
2007-06-14 | E-MEXP-1131 | biostudies-arrayexpress
ProteomicsTRANSCRIPTIONAL ACTIVATION BY E2F4 INDEPENDENT OF THE RB FAMILY
E2F transcription factors are central regulators of cell cycle progression and cell fate decisions in mammalian cells. E2F4 is a transcriptional repressor implicated in cell cycle arrest and whose repressive activity depends on its interaction with members of the RB family. E2F4 often represents the...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2019-04-26 | PXD008796 | Pride
Rb Pluripotency Embryonic stem cells P130 E2f4 Cell cycle P107 
GenomicsGenome-wide target discovery of transcripton factor E2F4 by ChIP-seq
The transcription factor E2F4 is a member of the E2F family of regulators which has critical roles in cell cycle control and differentiation. In order to fully understand the physiological roles of E2F4 and the regulatory networks it mediates, and to reveal its relationships with other members of th...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-21488 | biostudies-arrayexpress
TranscriptomicsWide-ranging fucntions of E2F4 in transcriptional activation and repression revealed by genome-wide analysis
The transcription factor E2F4 is a member of the E2F family of regulators which has critical roles in cell cycle control and differentiation. We investigated the genome-wide binding profile of E2F4 using a newly developed peak calling program based on a kernel density estimation and identified appro...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-21489 | biostudies-arrayexpress
ProteomicsRoles of USP2/E2F4 axis in autophagic machinery essential for cancer progression
We investigated the potential proteins degraded by E2F4-induced autophagy via quantitative proteomics. To gain insight into protein partner essential for E2F4 stability, co-immunoprecipitation and mass spectrometry assays were performed.
ORGANISM(S): Homo Sapiens 
2021-11-19 | PXD029858 |
ProteomicsThe E2F4/p130 repressor complex cooperates with oncogenic Np73 to promote cell survival
Tumor suppressor p53 and its related proteins, p63 and p73, can be synthesized as multiple isoforms lacking part of the N- or C-terminal regions. Specifically, high expression of the Np73 isoform is notoriously associated with poor prognosis in cancer. Here, we have performed proteomics analysis of ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-28 | PXD022947 | Pride
Cellular transformation E2f4 np73 Gene expression Protein-protein interactions P53 
TranscriptomicsChromatin immunoprecipitation of mouse and human cell lines and tissues using E2F4 antibodies
Despite being expressed in most tissues, a number of mammalian process-specific transcriptional regulators, such as those involved in cell cycle and immune responses, often have profound tissue-specific phenotypes. The mechanism underlying this effect is poorly understood. We chose to investigate ...
ORGANISM(S): Mus musculus 
2007-07-05 | E-TABM-272 | biostudies-arrayexpress
GenomicsThe Trim33 ubiquitin ligase limits E2f4-dependent DNA replication [Cut&Run II]
The Trim33 ubiquitin ligase limits E2f4-dependent DNA replication [Cut&Run II]
PRJNA986881 | ENA
GenomicsThe Trim33 ubiquitin ligase limits E2f4-dependent DNA replication [DSB]
The Trim33 ubiquitin ligase limits E2f4-dependent DNA replication [DSB]
PRJNA899471 | ENA
TranscriptomicsTranscription profiling of mouse wild type and E2F4 knockout neurospheres from E12.5 forebrain
E2F4 wild and knockout type neurospheres from E12.5 forebrain. E2F4 transcription factor regulates the expression of the genes which are required for neural stem cell expansion in the developing mouse brain. The results of microarray analysis will help to identify the signaling pathways affected by ...
ORGANISM(S): Mus musculus 
2008-04-08 | E-GEOD-10401 | biostudies-arrayexpress
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