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Proteomicsp140Cap Interactome - Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders
p140Cap is an adapter protein that is highly expressed in the brain. In particular, p140Cap localizes at dendritic spines where it contributes to the regulation of spine shape and maturation. We recently described that p140Cap knock-out mice present cognitive deficits, impaired long-term potentiatio...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-19 | PXD004215 | Pride
Synaptosome Nanolc-ms/ms P140cap 
Proteomicsp140Cap interactome in breast cancer cells
Even though neuronal and cancer cells have quite different purposes in the body, there is growing evidence that metastatic cancer cells implement signaling mechanisms found in homeostasis of synaptic growth/plasticity. Recent studies have highlight some remarkable similarities in both form and funct...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-25 | PXD008778 | Pride
Breast cancer Co-ip Nanolc-ms/ms P140cap 
Genomicsp140Cap overexpression in Balb-neuT HER2 breast cancer transgenic mice
p140Cap overexpression in Balb-neuT HER2 breast cancer transgenic mice
PRJNA735525 | ENA
Transcriptomicsp140Cap overexpression in Balb-neuT HER2 breast cancer transgenic mice
In HER2-positive breast cancer patients the adaptor protein p140Cap correlates with increased patient survival and decreased probability to develop metastasis. Causally, p140Cap negatively regulates in vitro and in vivo breast tumor properties. Here we show that p140Cap status correlates with a rewi...
ORGANISM(S): Mus musculus 
2022-12-19 | GSE176229 | GEO
UnknownThe p140Cap adaptor protein as a molecular hub to block cancer aggressiveness.
Not available
S-EPMC7904710 | biostudies-literature
Unknownp140Cap protein suppresses tumour cell properties, regulating Csk and Src kinase activity.
Not available
S-EPMC1894765 | biostudies-literature
UnknownThe SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma.
Not available
S-EPMC7205889 | biostudies-literature
UnknownP130Cas-associated protein (p140Cap) as a new tyrosine-phosphorylated protein involved in cell spreading.
Not available
S-EPMC329393 | biostudies-literature
UnknownEndophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap.
Not available
S-EPMC4387559 | biostudies-literature
Unknownp140Cap modulates the mevalonate pathway decreasing cell migration and enhancing drug sensitivity in breast cancer cells.
Not available
S-EPMC10733353 | biostudies-literature
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