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ProteomicsTargeting Saa expression via siRNA mitigates preterm birth induced by maternal inflammation
Introduction: Placental inflammation is a major contributor to preterm birth (PTB), and there are currently few targeted strategies to prevent PTB and its associated adverse neonatal outcomes. Serum amyloid A (SAA), particularly the isoforms SAA1 and SAA2, are well-recognized inflammatory markers, b...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-12 | PXD072875 | Pride
P2x7r-dependent signaling Raw264.7 cell line Saa2 Sirna-mediated targeting of saa2 
UnknownCirculating P2X7 Receptor Signaling Components as Diagnostic Biomarkers for Temporal Lobe Epilepsy.
Not available
S-EPMC8467140 | biostudies-literature
UnknownPI3K/Akt signaling pathway triggers P2X7 receptor expression as a pro-survival factor of neuroblastoma cells under limiting growth conditions.
Not available
S-EPMC4685307 | biostudies-literature
UnknownExtracellular ATP and IL-23 Form a Local Inflammatory Circuit Leading to the Development of a Neutrophil-Dependent Psoriasiform Dermatitis.
Not available
S-EPMC6251745 | biostudies-literature
TranscriptomicsAge-Dependent Effects of Macrophage Derived Cathelicidin Antimicrobial Peptide on Bone Fracture Repair
The pace of fracture repair declines with age, increasing the risk of delayed union and nonunion. Delayed union and nonunion are associated with significant morbidity and even mortality with few effective non-surgical interventions. Here, we identify cathelicidin antimicrobial peptide (CAMP) as an a...
ORGANISM(S): Mus musculus 
2026-10-02 | GSE345479 | GEO
UnknownPeroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation.
Not available
S-EPMC8818572 | biostudies-literature
UnknownIslet-Derived eATP Fuels Autoreactive CD8+ T Cells and Facilitates the Onset of Type 1 Diabetes.
Not available
S-EPMC6905486 | biostudies-literature
UnknownPoly (I:C)-induced inflammation requires the activation of toll-like receptor 3/Ca<sup>2+</sup>/CaMKII/pannexin 1-dependent signaling.
Not available
S-EPMC11840745 | biostudies-literature
UnknownActivation of P2X7 and P2Y11 purinergic receptors inhibits migration and normalizes tumor-derived endothelial cells via cAMP signaling.
Not available
S-EPMC5009337 | biostudies-literature
UnknownAge-Dependent Activation of Purinergic Transmission Contributes to the Development of Epileptogenesis in ADSHE Model Rats.
Not available
S-EPMC10886636 | biostudies-literature
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