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TranscriptomicsInfluence of human P53 on plant gene expression
Mammalian p53 is a super tumor suppressor and plays a key role in guarding genome from DNA damage. However, p53 has not been found in plants which do not bear cancer although they constantly expose to ionizing radiation of ultraviolet light. Here we introduced p53 into the model plant Arabidopsis an...
ORGANISM(S): Arabidopsis thaliana 
2016-06-26 | E-GEOD-79678 | biostudies-arrayexpress
ProteomicsReduced structural rigidity of MDMX protein enhances binding to TP53 mRNA
The two murine double minute (MDM) family members, MDM2 and MDMX are a well-established negative regulator of p53 activity. Under DNA damage conditions, MDM2 and MDMX are phosphorylated near their RING domains (serine 395 at MDM2 and serine 403 at MDMX) and switch to act as p53 positive regulators. ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD060074 | Pride
Human Mdmx-mdm2 interaction P53 mrna stabilization Ring domain Hdx-ms mapping Lc-ms/ms 
Transcriptomicsp53 In Inflamatory Stress Response
Activation of the p53 network plays a central role in the inflammatory stress response associated with ulcerative colitis, and may modulate cancer risk in patients afflicted with this chronic disease. The overall goal of these experiments is to study the gene expression profiles associated with four...
ORGANISM(S): Homo sapiens 
2005-11-30 | E-GEOD-3176 | biostudies-arrayexpress
TranscriptomicsGenes downstream of p53 mediating its effect on megakaryopoiesis
In order to examine genes whose expression is altered as a result of the knock-down (KD) of p53, we used gene expression microarray analysis based on the CHRF cell line, a human megakaryoblastic cell line, which upon PMA stimulation undergoes polyploidization, and extends proplatelet-like cytoplasmi...
ORGANISM(S): Homo sapiens 
2011-07-26 | E-GEOD-30984 | biostudies-arrayexpress
TranscriptomicsRNAseq of mouse embryonic fibroblasts from conditional knock-in mice carrying a phosphorylation-deficient S180A (SA) mutation in exon 5 of the endogenous mouse Trp53 gene locus
The mouse S180A (SA) mutation of the Trp53 is a p53 phosphorylation-deficient mutant protein with native conformation. Here we want to assess the impact of DNA binding site phosphorylation of the p53 target gene spectrum and transcriptional activity under untreated conditions and following p53 stabi...
ORGANISM(S): Mus musculus 
2020-08-25 | E-MTAB-9171 | biostudies-arrayexpress
UnknownHIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels.
Not available
S-EPMC48146 | biostudies-literature
UnknownMDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells.
Not available
S-EPMC3213308 | biostudies-literature
UnknownTranslocation of cytosolic human Cdc73 to stress granules plays a role in arsenic stress-induced stabilization of p53 mRNA.
Not available
S-EPMC10399996 | biostudies-literature
UnknownmRNA display selection of an optimized MDM2-binding peptide that potently inhibits MDM2-p53 interaction.
Not available
S-EPMC3057987 | biostudies-literature
TranscriptomicsInactivation of CDK2 is synthetic lethal to MYCN-overexpressing cancer cells
Two genes have a synthetic lethal relationship when silencing or inhibition of one gene is only lethal in the context of a mutation or activation of the second gene. This situation offers an attractive therapeutic strategy, as inhibition of such a gene will only trigger cell death in tumor cells wit...
ORGANISM(S): Homo sapiens 
2014-05-19 | E-GEOD-16480 | biostudies-arrayexpress
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