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TranscriptomicsThe differentiation/retrodifferentiation program of human U937 leukemia cells is accompanied by changes of VCP/p97
A possible functional role of VCP/p97 during differentiation of U937 cells was addressed by siRNA-targeting of VCP/p97. Functional changes in VCP-siRNA-transfected cells following phorbol ester-induced monocytic differentiation have been examind by DNA microarray analysis. Cells transfected with the...
ORGANISM(S): Homo sapiens 
2010-06-29 | E-GEOD-9821 | biostudies-arrayexpress
ProteomicsDifferential Impact of p97 Inhibitor CB-5083 on Protein Dynamics in Nucleus, Cytoplasm, and Membrane Compartments
Human p97/VCP is a vital AAA ATPase (ATPase associated with diverse cellular activity) plays critical roles in autophagy, endosomal trafficking, and the ubiquitin-proteasome system. Mutations in p97 cause inclusion body myopathy associated with paget’s disease of bone and frontotemporal dementia. P9...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056029 | Pride
P97 vcp P97 inhibitor  mass spectrometry. Cb-5083 
ProteomicsThe Phenyl Indole p97 inhibitor, UPCDC-30245, blocks endo-lysosomal degradation and coronavirus entry to host cells
Different modes of action small molecule inhibitors provide versatile tools for investigation of biology and development of therapeutics. However, to evaluate their exact mechanism of actions remains to be a challenging tas. We have identified two classes of p97 inhibitors, ATP competitive and allos...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD025822 | Pride
P97 inhibitor  proteomic  anti-virus 
ProteomicsInvestigation of interaction of p97, p37, PPI, SDS22 and Inhibitor-3 using cross-linking mass spectrometry (CL-MS)
In this project we investigated the complexes PPI/SDS22/Inhibitor-3 and p97/p37/PPI/SDS22/Inhibitor-3 by CL-MS using DSBU as crosslinker.
ORGANISM(S): Homo sapiens (Human) 
2024-11-22 | PXD026696 | Pride
Dsbu Ppi Inhibitor-3 Sds22 P97 
TranscriptomicsThe ERAD inhibitor Eeyarestatin I is a bifunctional compound with an ER localizing domain and a p97/VCP inhibitory group
Protein homeostasis in the endoplasmic reticulum (ER) has recently emerged as a therapeutic target for cancer treatment. Disruption of ER homeostasis results in ER stress, which is a major cause of cell death for cells exposed to the proteasome inhibitor Bortezomib, an anti-cancer drug approved for ...
ORGANISM(S): Homo sapiens 
2010-11-24 | E-GEOD-23849 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
ProteomicsTemporal proteomics of p97/VCP inhibition
To facilitate the development of p97 inhibitors as potential therapeutic agents and help define their clinical application, it is necessary to dissect the mechanism of action (MOA) of p97 inhibitors and compare them with proteasome inhibitors. Moreover, identifying specific cellular markers is criti...
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD025225 | Pride
Proteasome inhibitor Hct116 P97 inhibitor Proteomic 
ProteomicsTemporal proteomics of p97/VCP inhibition
To facilitate the development of p97 inhibitors as potential therapeutic agents and help define their clinical application, it is necessary to dissect the mechanism of action (MOA) of p97 inhibitors and compare them with proteasome inhibitors. Moreover, identifying specific cellular markers is criti...
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD025167 | Pride
Proteasome inhibitor Hct116 P97 inhibitor Proteomic 
ProteomicsTemporal proteomics of p97/VCP inhibition
To facilitate the development of p97 inhibitors as potential therapeutic agents and help define their clinical application, it is necessary to dissect the mechanism of action (MOA) of p97 inhibitors and compare them with proteasome inhibitors. Moreover, identifying specific cellular markers is criti...
ORGANISM(S): Homo sapiens (Human) 
2021-12-15 | PXD025094 | Pride
Proteasome inhibitor Hct116 P97 inhibitor Proteomic 
TranscriptomicsHCT116 cells treated with the p97 inhibitior CB-5083
The goal of this study was to analyze differential gene expression 8 hr after treatment of CB-5083, a small molecule inhibitor of p97 (VCP), in HCT116 cells grown in culture. DMSO treated cells were compared to cells treated with 1uM CB-5083 after 8 hr.
ORGANISM(S): Homo sapiens 
2015-11-09 | E-GEOD-73588 | biostudies-arrayexpress
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