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ProteomicsYeast poly(A)-binding protein (Pab1) controls translation initiation in vivo primarily by blocking mRNA decapping and decay
Poly(A)-binding protein (Pab1 in yeast) is involved in mRNA decay and translation initiation, but its molecular functions are incompletely understood. In this study, we employed a comprehensive multiomics strategy encompassing Ribosome profiling, spike-in normalized RNA-seq, SMPAT-seq, and CAGE-seq ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-07 | PXD052929 | Pride
Mrna decay Pab1 Yeast Translation 
GenomicsCoprinopsis cinerea AmutBmut pab1-1
Coprinopsis cinerea AmutBmut pab1-1 Transcriptome or Gene expression
PRJNA285427 | ENA
Proteomics0549_2 Fission yeast Pab1 interactome
We performed mass-spectrometry analysis of proteins co-purifying with the Pab1, the B55 regulatory subunit of the PP2A protein phosphatase complex. Pab1 was tagged with YFP at the C-terminus and expressed from its endogenous promoter at its chromosomal locus. After one hour of nitrogen starvation, P...
ORGANISM(S): Schizosaccharomyces pombe Schizosaccharomyces pombe 927 
2024-12-02 | PXD047697 | Pride
Fission yeast Pp2a Pab1-yfp interactome 
ProteomicsGFP:Pab1 interactome in EMM2-N 1hour
To look for Pab1 interacting proteins, GFP-Pab1 was purified from S. pombe cell under nitrogen depletion (cultureed in EMM2-N for 1hour) and subjected to LC-MS/MS analysis.
ORGANISM(S): Schizosaccharomyces pombe 
2024-12-02 | PXD047579 | Pride
Gfp-pab1 interactome Fission yeast Pp2a 
GenomicsPseudomonas aeruginosa PAb1
Strain being sequenced for comparative analysis
PRJNA28809 | ENA
ProteomicsDirect and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay
Cytoplasmic poly(A)-binding protein (PABPC, yeast Pab1) is involved in various stages of mRNA post-transcriptional control, including translation initiation, translation termination, and mRNA decay regulation. Due to the multi-functional properties of PABPC, attempts to define a specific role for PA...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-06-09 | PXD041495 | Pride
Poly(a)-binding protein Yeast Saccharomyces cerevisiae Pab1 Lc-msms 
GenomicsCoprinopsis cinerea AmutBmut pab1-1
Coprinopsis cinerea AmutBmut pab1-1 Genome sequencing
PRJNA258994 | ENA
ProteomicsHDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker
Poly(A)-binding protein (Pab1), a canonical stress granule marker, condenses upon heat shock or starvation, promoting adaptation, The molecular basis of condensation has remained elusive due to a dearth of techniques to probe structure directly in condensates. Here we apply hydrogendeuterium exchang...
ORGANISM(S): Escherichia coli 
2024-03-22 | PXD049463 | Pride
Hydrogen exchange Cellular stress response Mass spectrometry Pab1 Liquid-liquid phase separation 
GenomicsCoprinopsis cinerea AmutBmut pab1-1
Coprinopsis cinerea AmutBmut pab1-1 Gene Expression Profiling - CopciPectine3 transcriptome
PRJNA696185 | ENA
GenomicsCoprinopsis cinerea AmutBmut pab1-1
Coprinopsis cinerea AmutBmut pab1-1 Gene Expression Profiling - Copcicellulose1 transcriptome
PRJNA696186 | ENA
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