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GenomicsRibo-STAMP reveals translation status of RNAs bound by PABPN and PABPC
Ribo-STAMP reveals translation status of RNAs bound by PABPN and PABPC
PRJNA800802 | ENA
GenomicsDissection of Poly(A)-binding protein (PABPC) cellular function using degron-mediated depletion with replacement
Dissection of Poly(A)-binding protein (PABPC) cellular function using degron-mediated depletion with replacement
PRJNA1492714 | ENA
GenomicsDissection of Poly(A)-binding protein (PABPC) cellular function using degron-mediated depletion with replacement [Nanopore]
Dissection of Poly(A)-binding protein (PABPC) cellular function using degron-mediated depletion with replacement [Nanopore]
PRJNA1493196 | ENA
OtherRibo-STAMP reveals translation status of RNAs bound by PABPN and PABPC
The poly(A) tail appended to the 3’ end of many eukaryotic transcripts plays a key role in the stability, nuclear transport, and translation of the RNA. These roles are largely mediated by the Poly(A) Binding Proteins (PABPs) that coat the poly(A) tails and interact with various proteins involved in...
ORGANISM(S): Homo sapiens 
2022-03-30 | GSE195494 | GEO
TranscriptomicsDissection of Poly(A)-binding protein (PABPC) cellular function using degron-mediated depletion with replacement
Cytoplasmic poly(A)-binding proteins (PABPCs) are essential and highly abundant regulators of mRNA stability and translation, but their cellular functions have been difficult to dissect due to slow turnover and the lethality observed upon loss of both major paralogs, PABPC1 and PABPC4. To enable str...
ORGANISM(S): Homo sapiens 
2026-07-14 | GSE338197 | GEO
TranscriptomicsDissection of Poly(A)-binding protein (PABPC) cellular function using degron-mediated depletion with replacement [Nanopore]
Cytoplasmic poly(A)-binding proteins (PABPCs) are essential and highly abundant regulators of mRNA stability and translation, but their cellular functions have been difficult to dissect due to slow turnover and the lethality observed upon loss of both major paralogs, PABPC1 and PABPC4. To enable str...
ORGANISM(S): Homo sapiens 
2026-07-15 | GSE338309 | GEO
TranscriptomicsThe molecular basis of coupling between poly(A)-tail length and translational efficiency
In animal oocytes and early embryos, mRNA poly(A)-tail length strongly influences translational efficiency (TE), but later in development this coupling between tail length and TE disappears. Here, we elucidate how this coupling is first established and why it disappears. Overexpressing cytoplasmic p...
ORGANISM(S): Xenopus laevis Mus musculus Homo sapiens 
2021-07-07 | GSE166544 | GEO
ProteomicsDirect and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay
Cytoplasmic poly(A)-binding protein (PABPC, yeast Pab1) is involved in various stages of mRNA post-transcriptional control, including translation initiation, translation termination, and mRNA decay regulation. Due to the multi-functional properties of PABPC, attempts to define a specific role for PA...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-06-09 | PXD041495 | Pride
Poly(a)-binding protein Yeast Saccharomyces cerevisiae Pab1 Lc-msms 
OtherDirect and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay [Ribo-seq]
Cytoplasmic poly(A)-binding protein (PABPC, yeast Pab1) is involved in various stages of mRNA post-transcriptional control, including translation initiation, translation termination, and mRNA decay regulation. Due to the multi-functional properties of PABPC, attempts to define a specific role for PA...
ORGANISM(S): Saccharomyces cerevisiae 
2023-05-31 | GSE229692 | GEO
TranscriptomicsDirect and indirect consequences of PAB1 deletion in the regulation of translation initiation, translation termination, and mRNA decay [RNA-seq]
Cytoplasmic poly(A)-binding protein (PABPC, yeast Pab1) is involved in various stages of mRNA post-transcriptional control, including translation initiation, translation termination, and mRNA decay regulation. Due to the multi-functional properties of PABPC, attempts to define a specific role for PA...
ORGANISM(S): Saccharomyces cerevisiae 
2023-05-31 | GSE229691 | GEO
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