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ProteomicsShort poly(A) tails are protected from deadenylation by the LARP1-PABP complex
To find PABPC1-interactants in cells, PABPC1 immunoprecipitates were analyzed by LC-MS/MS
ORGANISM(S): Homo sapiens (Human) 
2022-08-20 | PXD028326 | Pride
Immunoprecipitation (ip) Pabpc1 Lc-ms/ms 
ProteomicsPABPC1 stress granule interactome identified by BioID
Identification of Stress Granule interacting proteins by BioID (Roux et al., 2012) using PABPC1-BirA(R118G)-GFP construct
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025334 | Pride
Stress granule Human Pabpc1 
ProteomicsDeubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma
Deubiquitinating PABPC1 by USP10 upregulates CLK2 translation to promote tumor progression in pancreatic ductal adenocarcinoma
ORGANISM(S): Homo 
2023-09-02 | PXD045063 |
TranscriptomicsATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice
Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)31. This is thought to mediate toxic gain-of-function by protein aggregation, and affect RNA processing, resulting in degenerative processes affecting preferenti...
ORGANISM(S): Mus musculus 
2012-07-24 | E-GEOD-39640 | biostudies-arrayexpress
ProteomicsMultivalent Interactions with CCR4-NOT and PABPC1 Determine mRNA Repression Efficiency by Tristetraprolin
Tristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation. The CCR4-NOT complex plays a central role in deadenylation, while the cytop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-30 | MSV000098386 | MassIVE
UnknownPABPC1--mRNA stability, protein translation and tumorigenesis.
Not available
S-EPMC9753129 | biostudies-literature
UnknownFunctional implications of PABPC1 in the development of ovarian cancer.
Not available
S-EPMC8122461 | biostudies-literature
ProteomicsPseudouridine-modified tRNA fragments repress malignant protein synthesis and predict leukemic progression in myelodysplastic syndrome
Transfer RNA (tRNA)-derived fragments (tRF) are emerging small noncoding (nc) RNAs that, while commonly altered in cancer, have poorly defined roles in tumorigenesis. Here we show that pseudouridylation (Ψ) of a stem-cell-enriched tRF subtype, mTOG, selectively inhibits malignant protein synthesis p...
ORGANISM(S): Homo sapiens (Human) 
2021-12-20 | PXD023122 | Pride
Rna modifications  development  hematopoiesis  pseudouridine  stem cells  trna fragments  translation control. hdx ms 
UnknownAtherosclerosis-related biomarker PABPC1 predicts pan-cancer events.
Not available
S-EPMC11103157 | biostudies-literature
GenomicsPABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules (RIP-Seq)
PABPC1 SUMOylation enhances cell survival by promoting mitophagy through stabilizing U-rich mRNAs within stress granules (RIP-Seq)
PRJNA1081913 | ENA
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