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MetabolomicsFood Deprivation Enhances Disease Resistance: Underlying Mechanisms in Oysters Confronted with Pacific Oyster Mortality Syndrome

Variation in food availability can shape host susceptibility and pathogen virulence, thereby impacting disease outcomes. An ad libitum diet may enhance host physiology and immunity but it can also favor pathogen proliferation. Here, we investigated how food availability (ad libitum vs. starvation...

2025-11-14 | MTBLS13313 | MetaboLights
MetabolomicsUnravelling age-driven molecular transitions underlying Pacific Oyster Mortality Syndrome permissiveness in Magallana gigas

Ageing is a progressive and irreversible biological process characterized by the deterioration of physiological functions and increased vulnerability to mortality. Although extensively studied in vertebrates, ageing in long-lived invertebrates remains comparatively unexplored. While ageing typica...

2025-12-08 | MTBLS13463 | MetaboLights
MetabolomicsNGT induced mitochondrial dysfunction, led to apoptosis, and changed metabolites associated with oxidized lipids in sperm of Pacific oyster (Crassostrea gigas).

The risk of norgestrel (NGT) exposure in the aquatic environment has been identified, but the toxic effects on invertebrate germ cells are unknown. Therefore, the toxic effects of NGT on oyster sperm were investigated by combining transcriptome and metabolome analysis with histology. Transcriptom...

2025-07-05 | MTBLS12685 | MetaboLights
MetabolomicsNorgestrel exposure accelerated the abnormal occurrence of germinal vesicle breakdown and triggered damage to cellular structure and function in oocytes of the Pacific oyster (Crassostrea gigas)

Progestins are ubiquitous in aquatic environments, with adverse effects on aquatic organisms' reproduction even at extremely low concentrations (0.8 ng/L). As female germ cells, oocytes play an irreplaceable role in organismal reproductive processes. However, the toxic mechanism of norgestrel (NG...

2025-09-10 | MTBLS12976 | MetaboLights
TranscriptomicsWhole transcriptome profiling of successful immune response to Vibrio infections in the oyster Crassostrea gigas by digital gene expression analysis
The cultivated Pacific oyster Crassostrea gigas has suffered for decades large scale summer mortality phenomenon resulting from the interaction between the environment parameters, the oyster physiological and/or genetic status and the presence of pathogenic microorganisms including Vibrio species. T...
ORGANISM(S): Crassostrea gigas 
2011-11-01 | E-GEOD-33390 | biostudies-arrayexpress
TranscriptomicsTranscriptome response to salinity stress in the Pacific oyster Crassostrea gigas
Low salinity is one of the main factors limiting the distribution and survival of marine species. As a euryhaline species, the Pacific oyster Crassostrea gigas can be tolerant to relative low salinity. Through Illumina sequencing, we generated two transcriptomes with samples taken from gills of oyst...
ORGANISM(S): Crassostrea gigas 
2012-12-15 | E-GEOD-38022 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Pacific oyster Crassostrea gigas under different developmental stages and stress treatments
Deep sequencing of samples from different development stages, different adult organs and different stress treatments of Pacific oyster Crassostrea gigas Samples of 38 developmental stages from egg to juvenile were analyzed using single-end 49 bp RNA-seq. Two libraries mixed by RNAs from different de...
ORGANISM(S): Crassostrea gigas 
2012-09-13 | E-GEOD-31012 | biostudies-arrayexpress
TranscriptomicsGenomic and transcriptomic landscapes of independent invasions of the Pacific Oyster Crassostrea gigas
Upon colonizing new habitats invasive species face a series of new selection pressures as a result of changing abiotic conditions and novel biotic interactions with native species. These new selection pressures can be accommodated by different mechanism that act on different levels and across differ...
ORGANISM(S): Crassostrea gigas 
2020-09-30 | E-MTAB-9186 | biostudies-arrayexpress
ProteomicsProteomic signatures of the Pacific oyster Crassostrea gigas cellular response to Ostreid herpes virus -1 (OsHV-1) infection: a metabolic response.
To better understand the pathogenesis of OsHV-1 and to determine which cell pathways might be affected during OsHV-1 infection, we used an experimental infection in the Pacific oyster Crassostrea gigas by intra-muscular injection with a low or high load of OsHV-1. Animals were sampled 2 days post-in...
ORGANISM(S): Crassostrea gigas (Pacific oyster) (Crassostrea angulata) 
2014-07-10 | PXD000905 | Pride
Crassostrea gigas Proteomics Marine bivalves Herpes virus 
Transcriptomicsoyster-OsHV-1 RNA-seq
Ostreid Herpesvirus type 1 (OsHV-1) has become a serious infective agent of the Pacific oyster livestock worldwide. In particular, the OsHV-1 muVar subtype has been associated to severe mortality episodes concerning Crassostrea gigas in France and other regions of the world such as Australia and New...
ORGANISM(S): Crassostrea gigas 
2014-12-31 | E-MTAB-2552 | biostudies-arrayexpress
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