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Objectives: To test whether (1) electromechanical dyssynchrony induces region-specific alterations in the myocardial transcriptome and (2) dyssynchrony-induced gene expression changes can be corrected by cardiac resynchronization (CRT). Background: To date, CRT is the only heart failure treatment th...
ORGANISM(S): Canis lupus familiaris 
Cardiac maturation is an important developmental phase where there are profound biological and functional changes after birth in mammals. Herein, we use our profiling of human heart maturation in vivo to identify key drivers of maturation in our human cardiac organoid (hCO) model. After screening of...
ORGANISM(S): Homo sapiens (Human) 
2025-04-17 | PXD054810 | Pride
Objectives: To test whether (1) electromechanical dyssynchrony induces region-specific alterations in the myocardial transcriptome and (2) dyssynchrony-induced gene expression changes can be corrected by cardiac resynchronization (CRT). Background: To date, CRT is the only heart failure treatment th...
ORGANISM(S): Canis lupus familiaris 
Trans-esophageal pacing induced changes in cardiac gene expression
This SuperSeries is composed of the following subset Series: GSE14327: Cardiac Resynchronization Therapy (1-color design) GSE14338: Cardiac Resynchronization Therapy (2-color design) Refer to individual Series
ORGANISM(S): Canis lupus familiaris 
Analysis of changes of gene expression profiles in the left ventricle (LV) during the progression of heart failure (HF) in the canine tachypacing induced HF model. Gene expression profiling was performed on samples collected at different time points representing various stages of LV dysfunction, i.e...
ORGANISM(S): Canis lupus familiaris 
Physiological Calcium Combined with Electrical Pacing accelerates Maturation of Human Engineered Heart Tissue
Left atrial tissue of rats exposed to rapid atrial pacing
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