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TranscriptomicsTranscription profiling of mouse liver to understand the regulation of hepatic gene expression by dwarfism and caloric restriction
Mice were killed between 24 to 26 months of age, tissues removed, rapidly frozen on dry ice, and stored in liquid nitrogen. Total liver RNA was isolated from frozen tissue as described (T. Tsuchiya, J.M. Dhahbi, X. Cui, P.L. Mote, A. Bartke, S.R. Spindler, Physiological Genomics, Submitted). mRNA le...
ORGANISM(S): Mus musculus 
2007-10-06 | E-GEOD-1093 | biostudies-arrayexpress
UnknownEffects of drought on the abundance and distribution of non-breeding shorebirds in central California, USA.
Not available
S-EPMC7577470 | biostudies-literature
UnknownSulphur cycling in a Neoarchaean microbial mat.
Not available
S-EPMC5412852 | biostudies-literature
TranscriptomicssiRNA profiling of human HeLa cells response to UPF1 depletion
Nonsense-mediated mRNA decay (NMD) is a molecular pathway of mRNA surveillance that ensures rapid degradation of mRNAs containing premature translation termination codons (PTCs) in eukaryotes. Originally, NMD was thought of as a quality control pathway that targets non-functional mRNAs arising from ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7009 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome analysis of erlotinib treatment in EGFR-mutant cells
We were interested in characterizing the transcriptional changes that occur on a genome-wide scale following treatment of EGFR-mutant lung cancer cells with targeted therapies. HCC827 human lung cancer cells harboring an amplified EGFR allele with an activating in frame deletion of 15 nucleotides in...
ORGANISM(S): Homo sapiens 
2015-02-25 | E-GEOD-51212 | biostudies-arrayexpress
TranscriptomicsRegulation of Mouse Lens Development and Gene Expression by Krüppel-Like Factor 4
Conditional disruption of Klf4 in the ectoderm-derived tissues of the eye results in defective cornea, conjunctiva and the lens. Expression of Klf4 is first detected in the embryonic day-12 (E12) mouse lens, peaks at E16, and declines thereafter. Lenses from Mice which were conditional null for Klf4...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-47694 | biostudies-arrayexpress
TranscriptomicsA Novel Model of Common TLR4- and Injury induced transcriptional themes in Human Leukocytes (supported by NIH grant GM34695)
Fifteen human volunteer subjects (18-40 years of age) and 5 Trauma patients were studied. One volunteer group (saline + LPS [n = 8]) received a 12 hour infusion a second volunteer group (cortisol + LPS [n = 7]) received a 12 hour infusion of cortisol (3 µg/kg/min). After 6 hours of saline or corti...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-22278 | biostudies-arrayexpress
TranscriptomicsEffect of PPARγ inhibition on pulmonary endothelial cell gene expression: Gene profiling in pulmonary hypertension
The loss of PPARγ is found to be associated with the development of pulmonary hypertension (PH). We hypothesize that PPARγ inhibition induced gene expression changes may underscore the endothelial dysfunction in the disease process. We utilized microarray analysis to determine gene expression chang...
ORGANISM(S): Bos taurus 
2009-12-27 | E-GEOD-14546 | biostudies-arrayexpress
TranscriptomicsDisruption of Ttll5/Stamp gene (Tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2 associated modulatory protein gene) in male mice causes sperm malformation and infertility
Tubulin tyrosine ligase-like family member 5 (TTLL5/STAMP) has multiple activities in cells. TTLL5 is one of 13 TTLLs, has polyglutamylation activity, augments the activity of p160 coactivators (SRC-1 and TIF2) in glucocorticoid receptor-regulated gene induction and repression, and displays steroid-...
ORGANISM(S): Mus musculus 
2013-03-28 | E-GEOD-45546 | biostudies-arrayexpress
TranscriptomicsDynamic changes in the functions of Klf5 in maturing mouse corneas revealed by the changes in its target genes at postnatal days 11 and 56
Purpose: Klf5 plays a critical role in the mouse ocular surface (Kenchegowda et al., 2011. Dev Biol. 356:5-18). Here, we compare wild-type (WT) and Klf5-conditional null (Klf5CN) corneal gene expression at postnatal day-11 (PN11) and PN56 to identify the Klf5-target genes. Methods: Gene expression ...
ORGANISM(S): Mus musculus 
2012-12-25 | E-GEOD-36229 | biostudies-arrayexpress
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