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ProteomicsNeutrophil-derived PAD4 induces citrullination of CKMT1 in epithelial cells to exacerbate mucosal inflammation
Objective Increased neutrophil extracellular trap-osis (NETosis) is a hallmark of inflammatory bowel disease (IBD). However, the mechanisms of NETosis formation and its detrimental effect on the intestinal epithelium remain poorly understood. Design Dextran sulfate sodium (DSS) induce colitis in pep...
ORGANISM(S): Mus musculus (Mouse) 
2025-06-09 | PXD041504 | Pride
Peptidyl-arginine deiminase-4  citrullination  mitochondrial creatine kinase 1  neutrophil extracellular traps  intestinal epithelial cells  inflammatory bowel disease 
ProteomicsCavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity
Arabidopsis pathogen effector-triggered immunity (ETI) is controlled by a family of three lipase-like proteins EDS1, PAD4 and SAG101 and two sub-families of HET-S/LOB-B (HeLo)-domain “helper” NLRs, ADR1s and NRG1s. EDS1-PAD4 dimers cooperate with ADR1s, and EDS1-SAG101 dimers with NRG1s, in two sepa...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-03-17 | PXD029477 | Pride
Nlr Eti Sag101 Pad4 Immunity Plant Eds1 
ProteomicsComparative analysis of PAD4 and SAG101 interactors upon activation of NLR immunity in Arabidopsis thaliana
Intracellular NLR receptors with a central nucleotide-binding domain allow plants to detect specific pathogen-secreted proteins and initiate immune signaling. A family of conserved Enhanced disease susceptibility 1 proteins with a lipase-like and the EP domain transduces the signal from activated NL...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-04-06 | PXD021301 | Pride
Arabidopsis Tnl Helper nlr Sag101 Pad4 Immunity 
TranscriptomicsGenes affected by PAD4 deficiency in LSK cells obtained from mouse bone marrow.
We found PAD4, which is one of the transcriptional co-regulator by histone modification, was highly expressed in lineage-, Sca-1+, c-kit+ (termed as LSK) cells of mouse bone marrow. To find the target genes which are regulated by PAD4 in LSK cells, we analyzed gene expression in PAD4-deficient mouse...
ORGANISM(S): Mus musculus 
2013-06-01 | E-GEOD-45482 | biostudies-arrayexpress
ProteomicsPAD4 controls tumor immunity via restraining the MHC-II machinery in macrophages
Tumor-associated macrophages (TAMs) shape tumor immunity and therapeutic efficacy. However, it is poorly understood if and how post-translational modifications (PTMs) intrinsically affect the phenotype and function of TAMs. Here, we found that peptidylarginine deiminase 4 (PAD4) manifested the highe...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD049188 | Pride
T cell Macrophage Pias Checkpoint Mhc Immunotherapy Tumor Pad4 Citrullination Stat1 
ProteomicsLiver metastatic growth in colorectal cancer depends on PAD4 leading to modification of the extracellular matrix by citrullination
Colorectal cancer is one of the most frequently occurring malignancies and a major cause of cancer death. Distant metastases in this disease most commonly develop in the liver and are often untreatable. Here, we show that citrullination of the extracellular matrix (ECM) by cancer cell derived pepti...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD010252 | Pride
Citrullination Liver Pad4 
ProteomicsThe EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity
Plants deploy cell surface and intracellular leucine rich-repeat domain (LRR) immune receptors to detect pathogens. LRR receptor kinases (LRR-RKs) and LRR receptor proteins (LRR-RPs) recognise microbe-derived molecules to elicit pattern-triggered immunity (PTI), whereas nucleotide-binding LRR (NLR) ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-07-05 | PXD026120 | Pride
Lrr receptor kinases Pad4 Arabidopsis immunity Lrr receptor proteins Eds1 
TranscriptomicsTranscription profiling of Arabidopsis leading to the identification of novel components in the EDS1/PAD4-regulated defence pathwayabidopsis-Pst-eds1-pad4
Gene expression profiling leading to the identification of novel components in the EDS1/PAD4-regulated defence pathway
ORGANISM(S): Arabidopsis thaliana 
2006-02-15 | E-MEXP-546 | biostudies-arrayexpress
Transcriptomicspad4 vs. pad4 est1b
This experiment was designed to identify transcripts which are changed in plants deficient for evolutionary conserved EST1B gene. A mutation in est1b leads to a constitutive up-regulation of a PAD4-dependent pathogen response pathway. To eliminate secondary effects of the constitutive pathogen respo...
ORGANISM(S): Arabidopsis thaliana 
2009-11-17 | E-GEOD-18979 | biostudies-arrayexpress
Transcriptomicspad4 vs. pad4 est1b
This experiment was designed to identify transcripts which are changed in plants deficient for evolutionary conserved EST1B gene. A mutation in est1b leads to a constitutive up-regulation of a PAD4-dependent pathogen response pathway. To eliminate secondary effects of the constitutive pathogen respo...
ORGANISM(S): Arabidopsis thaliana 
2009-11-18 | GSE18979 | GEO
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