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ProteomicsProteomics analysis of muscles from long lived O1/O3 flies in young and old age (Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations) Liam C. Hunt, Jianqin Jiao, Yong-Dong Wang, David Finkelstein, Deepti Rao, Michelle Curley, Maricela Robles-Murguia, Abbas Shirinifard, Vishwajeeth R. Pagala, Junmin Peng, Yiping Fan, and Fabio Demontis. Genome Research In press 2019.
Protein expression profiles in the whole tissue lysate extracted from the thorax of O1 and O3 long-lived flies with the control B3 strain flies and analyzed by tandem mass tag (TMT)–based mass spectrometry.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-06-13 | PXD014223 | Pride
Genomic analyses of aging  evolution of aging  circadian muscle transcriptome  longevity  circadian cycle  skeletal muscle  sarcopenia  proteostasis  timeless  drosophila 
UnknownProteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.
Not available
S-EPMC9925443 | biostudies-literature
UnknownCENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere.
Not available
S-EPMC4374629 | biostudies-literature
ProteomicsIdentification of JARID2/PRC2 interactome in human embryonic stem cells
JARID2 is an integral subunit of the chromatin modifier PRC2 (Polycomb Repressive Complex 2). PRC2 methylates lysine 27 in histone H3 and is required for human development. Mutaitons of PRC2 subunits have been frequently found in a variety of adult and pediatric cancer, suggesting that PRC2 critical...
ORGANISM(S): Homo sapiens (Human) 
2020-08-04 | PXD015670 | Pride
Human embryonic stem cells  pluripotency  jarid2  prc2  proteomics  proteome 
ProteomicsProteomic solubility changes induced by pathogenic human tau/MAPT during aging in Drosophila.
Aging and other proteostatic stresses can lead to accumulation of insoluble protein aggregates that disrupt normal cell function. We would like to identify these proteins accumulating in insoluble proteins fractions and better understand the molecular mechanisms of how these proteins accumulate.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2024-09-30 | PXD045325 | Pride
Tau/mapt  proteome insolubility  drosophila melanogaster. 
UnknownThe ubiquitin-conjugating enzyme UBE2D/eff maintains a youthful proteome and ensures protein quality control during aging.
Not available
S-EPMC10759998 | biostudies-literature
ProteomicsProteomic changes induced by knockdown of UBA1 and of E2 ubiquitin-conjugating enzymes in human HEK293 cells (UBE2Q1, UBE2QL1, UBER, UBE2S).Proteomic changes induced by knockdown of UBA1 and of E2 ubiquitin-conjugating enzymes in human HEK293 cells (Ctrl, CtrlHS, E2poolRNAi, E2poolRNAiHS)
The project goal is to identify the proteins that are regulated with loss of the E2 enzymes. In this study E2poolRNAi, E2poolRNAiHS were investigated.
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042341 | Pride
Uba1  e2 ubiquitin-conjugating enzymes  ubiquitin  human cells 
TranscriptomicsEfficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia
Alterations of IKZF1, encoding the lymphoid transcription factor IKAROS, are a hallmark of high risk acute lymphoblastic leukemia (ALL), however the role of IKZF1 alterations in ALL pathogenesis is poorly understood. Here we show that in mouse models of BCR-ABL1 leukemia, Ikzf1 and Arf alterations s...
ORGANISM(S): Mus musculus 
2015-09-04 | E-GEOD-68391 | biostudies-arrayexpress
UnknownLinear poly-ubiquitin remodels the proteome and influences hundreds of regulators in Drosophila.
Not available
S-EPMC11540324 | biostudies-literature
UnknownYbx1 fine-tunes PRC2 activities to control embryonic brain development.
Not available
S-EPMC7426271 | biostudies-literature
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