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UnknownA genome-wide study of DNA methylation patterns and gene expression levels in multiple human and chimpanzee tissues.
Not available
S-EPMC3044686 | biostudies-literature
TranscriptomicsThe Combination of a Genome-Wide Association Study of Lymphocyte Count and Analysis of Gene Expression Data Reveals Novel Asthma Candidate Genes
Recent genome-wide association studies (GWAS) have identified a number of novel genetic associations with complex human diseases. In spite of these successes, results from GWAS generally explain only a small proportion of disease heritability, an observation termed the M-bM-^@M-^\missing heritabilit...
ORGANISM(S): Homo sapiens 
2012-02-01 | E-GEOD-30697 | biostudies-arrayexpress
GenomicsAccurate inference of transcription factor binding from DNA sequence and chromatin accessibility data
Accurate functional annotation of regulatory elements is essential for understanding global gene regulation. Here, we report a genome-wide map of 827,000 transcription factor binding sites in human lymphoblastoid cell lines, which is comprised of sites correspond-ing to 239 position weight matrices ...
ORGANISM(S): Homo sapiens 
2010-11-15 | E-GEOD-25341 | biostudies-arrayexpress
TranscriptomicsEffect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data.
Next-generation sequencing has become an important tool for genome-wide quantification of DNA and RNA. However, a major technical hurdle lies in the need to map short sequence reads back to their correct locations in a reference genome. Here we investigate the impact of SNP variation on the reliab...
ORGANISM(S): Homo sapiens 
2009-10-22 | E-GEOD-18156 | biostudies-arrayexpress
GenomicsGenome-wide maps of nucleosome occupancy in human lymphoblastoid cell lines
Nucleosomes are important for gene regulation because their arrangement on the genome can control which proteins bind to DNA. Currently, few human nucleosomes are thought to be consistently positioned across cells; however, this has been difficult to assess due to the limited resolution of existing ...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-36979 | biostudies-arrayexpress
TranscriptomicsRegulatory element copy number differences shape primate expression profiles.
Gene expression differences are shaped by selective pressures and contribute to phenotypic differences between species. We identified 964 copy number differences (CNDs) of conserved sequences across 3 primate species and examined their potential effects on gene expression profiles. Samples with copy...
ORGANISM(S): Pan troglodytes 
2012-08-02 | E-GEOD-38572 | biostudies-arrayexpress
UnknownThe contribution of RNA decay quantitative trait loci to inter-individual variation in steady-state gene expression levels.
Not available
S-EPMC3469421 | biostudies-literature
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