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ProteomicsFunctional characterization of Phosphoenolpyruvate Carboxykinase 2 in Group 3 Medulloblastoma using Mass Spectrometry
Group 3 medulloblastoma (G3 MB) is an aggressive pediatric brain tumor subtype associated with poor prognosis and high metastasis, comprising about 20–25% of cases. G3 MB commonly features MYC amplification, which drives oncogenic transcription, enhanced biosynthesis, and metabolic rewiring to suppo...
ORGANISM(S): Homo Sapiens (human) 
2026-05-06 | PXD070897 | JPOST Repository
ProteomicsProteomic profiling of nuclear fractions of SMARCA4 knockdown samples in HDMB03
SMARCA4 mutations are common in Medulloblastoma but not much is understood about its pathobiology. In this study we prepared SMARCA4 knockdown models using a Group 3 medulloblastoma cell line called HDMB03 and investigated the proteomic changes. Nuclear enrichment was performed using hypertonic and ...
ORGANISM(S): Homo Sapiens (human) 
2026-03-25 | PXD070641 | JPOST Repository
ProteomicsProteomic profiling of in vitro knockdown of SMARCA4 in Medulloblastoma
SMARCA4 mutations are common in Medulloblastoma but not much is understood about its pathobiology. In this study we prepared SMARCA4 knockdown models using a Group 3 medulloblastoma cell line called HDMB03 and investigated the proteomic changes. We performed both DDA and DIA analyses and found that ...
ORGANISM(S): Homo Sapiens (human) 
2026-03-25 | PXD070640 | JPOST Repository
ProteomicsMRM for validation of Brain tumor biomarkers
The emergence of omics technologies over the last decade has helped in advancement of research and our understanding of complex diseases like brain cancers. However, barring genomics, no other omics technology has been able to find utility in clinical settings. The recent advancements in mass spectr...
ORGANISM(S): Homo Sapiens 
PXD024238 | panorama
ProteomicsValidation of detected viral and host peptides from COVID-19 nasopharyngeal swab samples
In the current scenario of COVID-19, an assay that can efficiently and specifically detect infection by SARS-COV2 is required. Nasopharyngeal swabs are non-invasive samples and can be conveniently acquired from the population to be screened. In this work, we have validated a few viral and host pepti...
ORGANISM(S): Homo Sapiens Severe Acute Respiratory Syndrome Coronavirus 2 
PXD021845 | panorama
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